1604048-08-9Relevant academic research and scientific papers
Synthesis of 2-acylthiophenes by palladium-catalyzed addition of thiophenes to nitriles
Jiang, Tao-Shan,Wang, Guan-Wu
supporting information, p. 369 - 373 (2014/05/20)
A direct synthesis of 2-acylthiophenes has been developed through palladium-catalyzed addition of thiophenes to nitriles. The reaction proceeded well under the palladium(II) acetate/2,2'-bipyridine system and using d-(+)-camphorsulfonic acid as the additive. In addition, the obtained 2-acylthiophenes could undergo further coupling reactions to generate novel products.
