160425-48-9Relevant articles and documents
Dynamic equilibrium of self-assembled cyclic trimer and tetramer of 1-methyl-5-imidazolylcobalt(III)porhyrin
Tanaka, Akira,Ryuno, Aya,Okada, Saori,Satake, Akiharu,Kobuke, Yoshiaki
, p. 281 - 291 (2005)
Dynamic equilibrium of self-assembled multi-porphyrin systems is of interest in obtaining switchable photoresponsive material, but rarely reported. 1-methyl-5-imidazolylcobalt(III)porphyrin (1Co) synthesized here assembled automatically into cyclic trimer and tetramer by intermolecular imidazolyl-cobalt(III) coordination. The trimer-tetramer equilibrium was dependent on concentration and solvent, as examined by NMR spectrometry. In CDCl3, the tetramer formation was favored at high concentrations, as the ratio of the trimer to the tetramer was 1:2 at 14.8 mM 1Co, and shifted to 1:8 at 74 mM. Further, when the sample was concentrated from a CHCl3 solution to dryness, the ratio increased to 1:24 on dissolution. In CD 3OD, on the other hand, only the trimer was observed in the wide concentration range. Accordingly, both the trimeric and the tetrameric structures could be prepared selectively by the choice of concentration and solvent.
A novel series of IKKβ inhibitors part II: Description of a potent and pharmacologically active series of analogs
Cushing, Timothy D.,Baichwal, Vijay,Berry, Karen,Billedeau, Roland,Bordunov, Viola,Broka, Chris,Browner, Michelle F.,Cardozo, Mario,Cheng, Peng,Clark, David,Dalrymple, Stacie,Degraffenreid, Michael,Gill, Adrian,Hao, Xiaolin,Hawley, Ronald C.,He, Xiao,Labadie, Sharada S.,Labelle, Marc,Lehel, Csaba,Lu, Pu-Ping,McIntosh, Joel,Miao, Shichang,Parast, Camran,Shin, Youngsook,Sjogren, Eric B.,Smith, Marie-Louise,Talamas, Francisco X.,Tonn, George,Walker, Keith M.,Walker, Nigel P.C.,Wesche, Holger,Whitehead, Chris,Wright, Matt,Jaen, Juan C.
scheme or table, p. 423 - 426 (2011/02/27)
A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our efforts at further optimization of this series, culminating in 2 with submicromolar potency in a HWB assay and efficacy in a CIA mouse model.
Studies on β-lactam antibiotics, synthesis and antibacterial activity of novel 1β-methylcarbapenems related to FR21818: 5-membered ring analogs
Azami, Hidenori,Barrett, David,Tanaka, Akira,Sasaki, Hiroshi,Matsuda, Keiji,Sakurai, Minora,Matsumoto, Yoshimi,Tawara, Shuichi,Chiba, Toshiyuki,Sakane, Kazuo
, p. 1409 - 1414 (2007/10/03)
The synthesis and biological activity of the novel series of 1β-methylcarbapenems 1 are described. Most compounds displayed extremely potent antibacterial activity and high renal DHP-I stability. The best compound in this series, FR21818 (1a) displayed ex