160485-42-7

Basic information

• Product Name: 1,2-Benzenedimethanol,3-fluoro-(9CI)
• Synonyms: 1,2-BENZENEDIMETHANOL, 3-FLUORO;(3-Fluoro-2-hydroxymethylphenyl)methanol;1,2-Benzenedimethanol,3-fluoro-(9CI);3-Fluoro-1,2-bis(hydroxyMethyl)benzene;3-fluoro-1,2-BenzenediMethanol;(3-Fluoro-1,2-phenylene)dimethanol
• CAS NO: 160485-42-7
• Molecular Formula: C₈H₉FO₂
• Molecular Weight: 156.155
• Product Categories: HALIDE
• Mol File: 160485-42-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 282.779 °C at 760 mmHg
• Flash Point: 124.821 °C
• Appearance: /
• Density: 1.288 g/cm³
• CAS DataBase Reference: 1,2-Benzenedimethanol,3-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenedimethanol,3-fluoro-(9CI)(160485-42-7)
• EPA Substance Registry System: 1,2-Benzenedimethanol,3-fluoro-(9CI)(160485-42-7)

Safety Data

• Hazardous Substances Data: 160485-42-7(Hazardous Substances Data)

Usage

General Description

1,2-Benzenedimethanol,3-fluoro-(9CI) is a chemical compound that belongs to the category of aromatic alcohols. It is also known by its systematic name: 3-Fluoro-1,2-benzenedimethanol. This organic compound features a benzene ring substituted with two methanol groups at the 1,2 positions and one fluorine atom at the 3 position. The details regarding its properties such as melting point, boiling point, density, and molar mass are not readily available, indicating that it is not widely studied or utilized in industry. The chemical's potential applications and toxicological impact have not been extensively explored. This suggests it may be a niche or novel compound in the realm of organic chemistry.

Upstream product

• 443-82-3 3-fluoro-o-xylene 
• 183448-41-1 3-fluorophthalic acid, dimethyl ester 
• 1158357-44-8 2-(ethoxycarbonyl)-6-fluorobenzoic acid 
• 27563-65-1 3-chlorobenzene-1,2-dicarboxylic acid 
• 652-39-1 3-fluorophthalic anhydride 

Downstream Products

• 1158357-56-2 Methanesulfonic Acid 2-fluoro-6-methanesulfonyloxymethyl-benzyl Ester 
• 113600-16-1 1,2-bis<(triphenylphosphonio)methyl>-3-fluorobenzene dibromide 
• 161747-14-4 3-fluorobenzene-1,2-dicarbaldehyde 
• 62590-16-3 α,α'-dibromo-3-fluoro-o-xylene 

Relevant articles and documents

Novel Substituted Poly(benzothiophenes); Controlling the n- and p-Doping Potentials

Methyl-, chloro- and fluoro-substitution in the C6 ring has little effect on the oxidation of polybenzothiophene films to the p-doped conducting form, but has a marked effect on reduction to the n-doped form; poly(5,6-dichlorobenzothiophene) is n-do

Fluorescent Isoindole Crosslink (FlICk) Chemistry: A Rapid, User-friendly Stapling Reaction

The stabilization of peptide secondary structure via stapling is a ubiquitous goal for creating new probes, imaging agents, and drugs. Inspired by indole-derived crosslinks found in natural peptide toxins, we employed ortho-phthalaldehydes to create isoindole staples, thus transforming inactive linear and monocyclic precursors into bioactive monocyclic and bicyclic products. Mild, metal-free conditions give an array of macrocyclic α-melanocyte-stimulating hormone (α-MSH) derivatives, of which several isoindole-stapled α-MSH analogues (Ki≈1 nm) are found to be as potent as α-MSH. Analogously, late-stage intra-annular isoindole stapling furnished a bicyclic peptide mimic of α-amanitin that is cytotoxic to CHO cells (IC50=70 μm). Given its user-friendliness, we have termed this approach FlICk (fluorescent isoindole crosslink) chemistry.

Preparation of dihydropyrrol derivatives as intermediates

The invention is concerned with a new scalable process for the preparation of compounds of formula I comprising a new process for the preparation of the key intermediate, a dihydropyrrole derivative formula II or a salt thereof.