27563-65-1

Usage

Uses

Used in Polymer Synthesis:
3-Chlorophthalic acid is used as a key intermediate for the production of polyester resins, which are essential in the manufacturing of plastics, coatings, and adhesives. Its role in polymer synthesis is vital for creating durable and versatile materials used across different industries.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-chlorophthalic acid is utilized as an intermediate in the synthesis of various drugs. Its chemical properties make it a valuable component in the development of new medications, contributing to advancements in healthcare.
Used in Agrochemical Production:
Similarly, in the agrochemical sector, 3-chlorophthalic acid is employed as an intermediate for the production of pesticides and other agricultural chemicals. Its involvement in this area is essential for enhancing crop protection and increasing agricultural productivity.
Safety Note:
Given its classification as a hazardous substance, 3-chlorophthalic acid requires careful handling to prevent skin and eye irritation, ensuring safety in its application across various industries.

InChI:InChI=1/C8H5ClO4/c9-5-3-1-2-4(7(10)11)6(5)8(12)13/h1-3H,(H,10,11)(H,12,13)

Upstream product

• 1825-30-5 1,5-dichloronaphthalene 
• 3468-80-2 5-chloro-1,2,3,4-tetrahydronaphthalene 
• 858199-05-0 (1,8-dichloro-[2]naphthyl)-methyl ether 
• 608-23-1 3-chloro-o-xylene 
• 7499-08-3 3-chloro-2-methylbenzoic acid 
• 64-19-7 acetic acid 
• 2050-72-8 1,6-dichloronaphthalene 
• 7697-37-2 nitric acid 
• 603-11-2 3-nitrophthalic acid 
• 615-60-1 4-chloro-1,2-dimethylbenzene 
• 117-21-5 3-chlorophthalic anhydride 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 90-13-1 1-Chloronaphthalene 
• 118-45-6 4-chlorophthalic anhydride 

Downstream Products

• 75990-94-2 1-methyl hydrogen-3-chlorophthalate 
• 51108-30-6 4-chloro-1H-isoindole-1,3(2H)-dione 
• 117-21-5 3-chlorophthalic anhydride 
• 245064-92-0 1,4-dihydroxy-5-chloro-9,10-anthraquinone 
• 61539-35-3 3-chlorophthalic acid dimethyl ester 
• 63196-12-3 3-phenoxy-phthalic acid 
• 610-35-5 4-hydroxyphthalic acid 
• 110706-48-4 3-chloro-1,2-di-(hydroxymethyl)benzene 
• 118-45-6 4-chlorophthalic anhydride 
• 160485-42-7 (3-fluoro-1,2-phenylene)dimethanol 
• 37418-88-5 3-hydroxyphthalic anhydride 
• 1013915-44-0 4-chloro-1,3-dihydroisobenzofuran 

Relevant academic research and scientific papers

Solubility of 3-chlorophthalic anhydride and 4-chlorophthalic anhydride in organic solvents and solubility of 3-chlorophthalic acid and 4-chlorophthalic acid in water from (283.15 to 333.15) K

The solubility of 3-chlorophthalic anhydride and 4-chlorophthalic anhydride in ethyl acetate, acetone, and 1,4-dioxane and the solubility of 3-chlorophthalic acid and 4-chlorophthalic acid in water were measured using Schreinemaker's wet residue method at

Naphthalenes Oxidation by Aqueous Sodium Hypochlorite Catalyzed by Ruthenium Salts under Phase-Transfer Catalytic Conditions

Highly effective and fast oxidation of naphthalene(s) to phthalic acid(s) under biphasic conditions using nominal catalyst loading (0.5 mol%) of ruthenium chloride, 2.5 mol% tetrabutyl ammonium bromide as phase transfer catalyst and inexpensive aqueous sodium hypochlorite (NaOCl) as reagent has developed. Recovery, regeneration and reuse of the catalytic system add its merit to green chemistry.

Preparation method for biphenyltetracarboxylic dianhydride mixture

The invention relates to a preparation method for a biphenyltetracarboxylic dianhydride mixture. The preparation method comprises the following steps: with phthalic acid as a starting raw material, carrying out an electrophilic substitution reaction so as to produce a phthalic acid derivative; then subjecting the derivative to esterification so as to produce phthalate; further catalyzing phthalate and carrying out a coupling reaction so as to produce a biphenyl tetraformate mixture; and finally, successively carrying out saponification and acidification so as to produce the product biphenyltetracarboxylic dianhydride mixture. The method provided by the invention uses cheap and easily phthalic acid as the starting raw material and is a novel low-cost easily-operatable environment-friendly production method for biphenyltetracarboxylic dianhydride; moreover, isomeric compounds of all the biphenyltetracarboxylic dianhydride are synthesized at one time in the invention, so efficiency is improved and the cost is reduced.

COMPOUNDS USEFUL AS CCR9 MODULATORS

The present invention relates to compounds useful as CCR9 modulators, to compositions containing them, to methods of making them, and to methods of using them. In particular, the present invention relates to compounds capable of modulating the function of the CCR9 receptor by acting as partial agonists, antagonists or inverse agonists. Such compounds may be useful to treat, prevent or ameliorate a disease or condition associated with CCR9 activation, including inflammatory and immune disorder diseases or conditions such as inflammatory bowel diseases (IBD).

Method of making halophthalic acids and halophthalic anhydrides

A method of preparing a halophthalic acid is disclosed which comprises the steps of contacting in a liquid phase reaction mixture at least one halogen-substituted ortho-xylene with oxygen and acetic acid at a temperature in a range between about 120° C. and about 220° C. in the presence of a catalyst system yielding a product mixture comprising less than 10 percent halogen-substituted ortho-xylene starting material, a halophthalic acid product, and less than about 10,000 ppm halobenzoic acid and less than about 1000 ppm halophthalide by-products based on a total amount of halophthalic acid present in the product mixture. In addition a method for the preparation of halophthalic anhydride is also disclosed.

Ortholithiation of unprotected benzoic acids: Application for novel 2-chloro-6-substituted benzoic acid syntheses

2-Chloro-6-substituted benzoic acids of the type 2a-h were prepared by the tandem metallation sequence from 2-chlorobenzoic acid 1 with the 1:1 complex secbutyllithium/TMEDA in THF at -78°C followed by quenching with electrophiles.

Method for removing impurities from oxidation products

Disclosed is a method for removing impurities from products derived from oxidation of an ortho-dialkylaromatic compound which comprises at least one step selected from the group consisting of extraction of an aqueous solution comprising aromatic dicarboxylic acid product with an organic solvent and extraction of an organic solution comprising aromatic anhydride product with an aqueous bicarbonate solution for a time period insufficient to allow hydrolysis of anhydride to acid.

METHOD FOR THE MANUFACTURE OF CHLOROPHTHALIC ANHYDRIDE

A method for the manufacture of chlorophthalic acid by liquid phase oxidation of chloro-ortho-xylene is disclosed. The chlorophthalic acid may be dehydrated to form chlorophthalic anhydride which is useful in the synthesis of polyetherimide.

On the regioselectivity of metal hydride reductions of 3-substituted phthalic anhydrides

A problem of 3-methoxyphthalide reduction by metal hydrides was reinvestigated. Various effects controlling selectivity of reductions in 3-substituted phthalides were studied, and a qualitative interpretation of the results is now proposed. Methods for obtaining enhanced yields of one or the other lactonic product were developed.