1605274-11-0Relevant articles and documents
Direct C-H difluoromethylenephosphonation of arenes and heteroarenes with bromodifluoromethyl phosphonate via visible-light photocatalysis
Wang, Lin,Wei, Xiao-Jing,Lei, Wen-Long,Chen, Han,Wu, Li-Zhu,Liu, Qiang
, p. 15916 - 15919 (2014)
This communication reports a room temperature visible-light-driven protocol for the C-H difluoromethylenephosphonation of arenes and heteroarenes. Using commercially available diethyl bromodifluoromethyl phosphonate as a precursor of difluoromethyl radical, fac-Ir(ppy)3 as a photosensitizer and a 3 W blue LED as a light source, an array of aromatic compounds containing difluoromethylenephosphonyl groups were prepared directly from the corresponding arenes and heteroarenes in excellent to moderate yields.
Silver-Mediated C–H Difluoromethylation of Arenes
Li, Jialiang,Wan, Wen,Ma, Guobin,Chen, Yunrong,Hu, Qingyang,Kang, Kai,Jiang, Haizhen,Hao, Jian
supporting information, p. 4916 - 4921 (2016/10/13)
The first AgI-mediated C–H ethoxycarbonyl difluoromethylation with TMSCF2COOEt (TMS = trimethylsilyl) has been developed. The radical difluoromethylation proceeds smoothly to give the difluoromethylated arenes in moderate to high yie
Palladium-catalyzed difluoroalkylation of aryl boronic acids: A new method for the synthesis of aryldifluoromethylated phosphonates and carboxylic acid derivatives
Feng, Zhang,Min, Qiao-Qiao,Xiao, Yu-Lan,Zhang, Bo,Zhang, Xingang
supporting information, p. 1669 - 1673 (2014/03/21)
The palladium-catalyzed difluoroalkylation of aryl boronic acids with bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been developed. This method provides a facile and useful access to a series of functionalized difluoromethylated arenes (ArCF2PO(OEt) 2, ArCF2CO2Et, and ArCF2CONR 1R2) that have important applications in drug discovery and development. Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway may be involved in the catalytic cycle. Palladium does it: The palladium-catalyzed difluoroalkylation of aryl boronic acids with bromodifluoromethylphosphonate, bromodifluoroacetate, and further derivatives has been developed (see scheme). Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway may be involved in the catalytic cycle. Copyright
