1605293-68-2Relevant academic research and scientific papers
Synthetic approaches towards the sulfonamide substituted-1,5- diarylimidazole-2-thiones as selective cyclooxygense-2 inhibitors
Navidpour, Latifeh,Amini, Mohsen,Miri, Ramin,Firuzi, Omidreza,Tavakkoli, Marjan,Shafiee, Abbas
, p. 71 - 79 (2014/02/14)
A new series of sulfonamide substituted 1,5-diarylimidazole, possessing C-2 alkylthio moiety, were synthesized for their cyclooxygense-2 (COX-2) inhibitory activity starting from condensation of N,N-dibenzylaminosulfonylphenacylamine hydrochloride (2) and corresponding isothiocyanate in the presence of Et 3N, followed by alkylation in the basic medium. In concomitant with these intermediates, 2-arylamino-5-arylthiazole derivatives 5 were also produced. The ratio of these two products was variable with different isothiocyanates. Final debenzylation was achieved using concentrated sulfuric acid to give the title sulfonamides 8.
