1605296-07-8

Basic information

• Product Name: 5-fluoro-3-((thiophen-2-ylmethylene)hydrazono)indolin-2-one
• Synonyms: 5-fluoro-3-((thiophen-2-ylmethylene)hydrazono)indolin-2-one
• CAS NO: 1605296-07-8
• Molecular Weight: 273.29
• Mol File: 1605296-07-8.mol

Chemical Properties

• CAS DataBase Reference: 5-fluoro-3-((thiophen-2-ylmethylene)hydrazono)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-3-((thiophen-2-ylmethylene)hydrazono)indolin-2-one(1605296-07-8)
• EPA Substance Registry System: 5-fluoro-3-((thiophen-2-ylmethylene)hydrazono)indolin-2-one(1605296-07-8)

Safety Data

• Hazardous Substances Data: 1605296-07-8(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 1401343-77-8 (Z)-5-Fluoro-3-hydrazonoindolin-2-one 

Relevant articles and documents

Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents

The docking studies on CDK2 and GSK-3β inspired us to synthesis a series of indoline-2,3-dione hydrazones 10a-l. Treatment of indoline-2,3-dione derivatives 7a-d with hydrazine gave 3-hydrazonoindolin-2-ones 8a-d which were reacted with the appropriate aldehydes 9a-c to yield 3-substituted- (methylenehydrazono)indolin-2-ones 10a-l. Compounds 10a-l showed a significant anticancer activity against human breast cell line MCF-7. Compounds 10c, f, i exhibited the highest activity almost the same of doxorubicin (IC50 = 6.10 μM) with IC50 = 7.75, 6.75, 6.25 μM, respectively.