1605302-52-0Relevant academic research and scientific papers
Synthesis of 3,5,5-trisubstituted 4-hydroxy-4H,5H-1,2,4-oxadiazoles through the condensation of N-hydroxyamidoximes and ketones or aldehydes
Liu, Ning,Zhai, Lian-Jie,Lian, Peng,Li, Hui,Wang, Bo-Zhou
, p. 2965 - 2971 (2015)
An interesting class of heterocyclic compounds, 1,2,4-oxadiazoles and their derivatives have attracted the attention of chemists because of their use in the development of new pharmaceuticals and functional materials. Herein, a catalyst-free reaction of N-hydroxyamidoxime with various ketones or aldehydes has been investigated. The reaction was carried out in methanol under mild conditions and gave 3,5,5-trisubstituted 4-hydroxy-4H,5H-1,2,4-oxadiazole derivatives in excellent yields. The structure of product 3f was confirmed by single-crystal X-ray diffraction studies.
Synthesis and characterization of para-substituted N,N′- dihydroxybenzamidines and their derivatives as model compounds for a class of prodrugs
Schwarz, Laura,Girreser, Ulrich,Clement, Bernd
, p. 1961 - 1975 (2014/04/03)
A synthetic strategy for previously unknown para-substituted N,N′-dihydroxybenzamidines and their O-monosubstituted and O,O′-disubstituted methyl, benzyl, and tetrahydropyranyl derivatives is described. The procedure starts with the corresponding hydroxam
