1605320-01-1

Upstream product

• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 86795-49-5 3-(phenyl-λ³-iodanylidene)chromane-2,4-dione 
• 86396-02-3 2-(phenyl-λ³-iodaneylidene)cyclohexane-1,3-dione 
• 5669-19-2 2-Benzyl-2-propenoic acid 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 

Relevant academic research and scientific papers

Experimental and theoretical study of the spectroscopic properties and the preparation of 3-benzyl-2H-pyrano[3,2-c]chromene-2,5(6H)-dione

Compound 3-benzyl-2H-pyrano[3,2-c]chromene-2,5(6H)-dione(3), was prepared and fully characterized. The vibrational modes (FT-IR) and NMR data ( 1H and 13C chemical shifts) were compared with the results of Density Functional Theory (

Method for preparing cyclohexanone/chromenopyrone compounds and application of cyclohexanone/chromenopyrone compounds

The invention provides a method for preparing cyclohexanone/chromenopyrone compounds and application of the cyclohexanone/chromenopyrone compounds, and belongs to the field of organic chemistry. In the presence of a rhodium catalyst, alpha, beta-unsaturated carboxylic acid reacts with 1,3-cyclohexanedione-2-phenyl iodide or 4-hydroxychromene-2-one-2-phenyl iodide, and the cyclohexanone/chromenopyrone compounds are obtained with high selectivity. The method has the advantages of mild reaction conditions, short reaction steps, simple post-treatment and high stereoselectivity and regioselectivityof the reaction product. Meanwhile, the cyclohexanone pyrone compound shows good activity in inhibition of a plurality of cancer cells.

Iodonium Ylides as Carbene Precursors in Rh(III)-Catalyzed C-H Activation

The rhodium(III)-catalyzed coupling of C-H substrates with iodonium ylides has been realized for the efficient synthesis of diverse cyclic skeletons, where the iodonium ylides have been identified as efficient and outstanding carbene precursors. The reaction systems are applicable to both sp2 and sp3 C-H substrates under mild and redox-neutral conditions. The catalyst loading can be as low as 0.5 mol % in a gram-scale reaction. Representative products exhibit cytotoxicity toward human cancer cells at nanomolar levels.