160596-95-2Relevant academic research and scientific papers
SYNTHESIS OF SOME PHENYLAZOPYRIDOTHIENOPYRIMIDINES
El-Dean, Adel M. Kamal
, p. 85 - 94 (2007/10/02)
2-Mercapto-5-phenylazo-4,6-dimethylpyridine-3-carbonitrile (3) reacts with halocompounds to give S-alkylated derivatives (4a-h) which upon treatment with sod. ethoxide in ethanol, the thienopyridines (5a-h) was obtained.Compound (5) converted into pyridothienopyrimidines (6a-e) or (7a,b) boiling with triethyl orthoformate or acetic anhydride.Also it can be converted into pyridothienotriazine (8a-d) by treating with nitrous acid.Chloropyridothienopyrimidine (10a,b) was obtained by refluxing compound 6a or 7a with POCl3.Key words: Synthesis, reactions, thienopyridine, pyridothienopyrimidine, pyridothienotriazine.
