6134-57-2

Usage

Uses

Used in Organic Synthesis:
Pentane-2,3,4-trione 3-phenylhydrazone is used as a reagent in the preparation of organic compounds for its ability to form complexes with a variety of metal ions, enhancing the synthesis process.
Used in Research and Development Laboratories:
Pentane-2,3,4-trione 3-phenylhydrazone is used as a research tool for its ability to form complexes with metal ions, aiding in the study of metal ion interactions and their applications in various fields.
Used in Chemical Sciences:
Pentane-2,3,4-trione 3-phenylhydrazone is utilized in chemical sciences for its potential biological activities, such as antioxidant and antibacterial properties, contributing to the development of new chemical entities with these properties.
Used in Biological Sciences:
In biological sciences, Pentane-2,3,4-trione 3-phenylhydrazone is employed for its potential biological activities, which can be explored for applications in medicine and biotechnology, such as the development of new drugs or antimicrobial agents.

InChI:InChI=1/C11H12N2O2/c1-8(14)11(9(2)15)13-12-10-6-4-3-5-7-10/h3-7,12H,1-2H3

Upstream product

• 15435-71-9 sodium acetylacetonate 
• 100-34-5 benzene diazonium chloride 
• 7647-01-0 hydrogenchloride 
• 3762-55-8 3-phenylhydrazono-4-imino-2-pentanone 
• 62-53-3 aniline 
• 123-54-6 acetylacetone 

Downstream Products

• 36845-81-5 1-(5-methyl-1-phenyl-1H-pyrazol-3-yl)-ethanone 
• 5335-37-5 3-acetyl-1,5-diphenylformazan 
• 75872-29-6 1-<1,6-Dihydro-4-methyl-1-phenyl-6-(phenylimino)-3-pyridazinyl>ethanon 
• 70826-56-1 1-(4,6-dimethylpyrimidin-2-yl)-3,5-dimethyl-4-phenyl-azopyrazole 
• 100621-53-2 5-(phenylazo)-3-cyano-4,6-dimethyl-pyridine-2-(1H)-thione 
• 75872-28-5 6-acetyl-5-methyl-2-phenylpyridazin-3(2H)-one 
• 75872-30-9 1-<1,6-Dihydro-6-(9-fluorenyliden)-4-methyl-1-phenyl-3-pyridazinyl>ethanon 
• 75872-29-6 1-{4-Methyl-1-phenyl-6-[(E)-phenylimino]-1,6-dihydro-pyridazin-3-yl}-ethanone 
• 24756-10-3 3-(2-(2-nitrophenyl)hydrazineylidene)pentane-2,4-dione 
• 50711-98-3 pentane-2,3,4-trione-3-(4-nitro-phenylhydrazone) 
• 129302-56-3 3-(N-Nitro-N-phenylhydrazono)pentane-2,4-dione 
• 139038-76-9 (Z)-4-[2-((Z)-1-Methyl-3-oxo-2-phenylazo-but-1-enylamino)-ethylamino]-3-phenylazo-pent-3-en-2-one 
• 29541-37-5 4-{(E)-4-[1-Methyl-3-oxo-2-(phenyl-hydrazono)-but-(E)-ylideneamino]-butylimino}-3-(phenyl-hydrazono)-pentan-2-one 
• 137156-86-6 acetic acid-[(1-acetyl-2-oxo-propylidene)-phenyl-hydrazide] 

Relevant academic research and scientific papers

Reversible switching of arylazopyrazole within a metal-organic cage

Arylazopyrazoles represent a new family of molecular photoswitches characterized by a near-quantitative conversion between two states and long thermal half-lives of the metastable state. Here, we investigated the behavior of a model arylazopyrazole in the

Photoresponsive host-guest chemistry and relaxation time of fluorinated cyclodextrin and T1=T* 2 arylazopyrazole-functionalized DOTA metal complexes

Light-responsive modulation of the longitudinal (T1) and transversal T *2) relaxation times of a fluorinated cyclodextrin has been achieved by host-guest complexation with arylazopyrazole-modified metal complexes in aqueous solution. This supramolecular concept can potentially be applied to the development of contrast agents for19F magnetic resonance imaging (MRI).

Chemoproteomics-Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism

Herein, we report arylazopyrazole ureas and sulfones as a novel class of photoswitchable serine hydrolase inhibitors and present a chemoproteomic platform for rapid discovery of optically controlled serine hydrolase targets in complex proteomes. Specifica

ARYLAZO-HETEROARYL COMPOUNDS AND THEIR USE FOR LONG-TERM THERMAL ENERGY STORAGE

The present invention relates to a compound of Formula (I): wherein R1, R2, m, n, p, Q, X, Y, W, and "A" are as described herein. The present invention also relates to a process for preparation of a compound of Formula (I). Also disclosed is a thermal-storage device comprising one or more compounds of Formula (I) and a method of storing energy.

Mixed isatin with 3-(2-(aryl)hydrazono)acetylacetone mn(ii), co(ii) and ni(ii) complexes: Antibacterial evaluation and molecular properties prediction

The metal complexes {Ni (II), Co (II) and Mn (II)} of 3-(2-(aryl)hydrazono)acetylacetone with isatin were synthesized and screened for their in vitro antibacterial activity against four pathogenic microorganisms {two Gram-positive and two Gram negative}.

Photoresponsive Zn2+-specific metallohydrogels coassembled from imidazole containing phenylalanine and arylazopyrazole derivatives

Stimuli-responsive supramolecular gels and metallogels have been widely explored in the past decade, but the fabrication of metallogels with reversible photoresponsive properties remains largely unexplored. In this study, we report the construction of pho

Arylazopyrazoles for Long-Term Thermal Energy Storage and Optically Triggered Heat Release below 0 °c

Arylazopyrazole derivatives based on four core structures (4pzMe, 3pzH, 4pzH, and 4pzH-F2) and functionalized with a dodecanoate group were demonstrated to store thermal energy in their metastable Z isomer liquid phase and release the energy by optically triggered crystallization at -30 °C for the first time. Three heat storage-release schemes were discovered involving different activation methods (optical, thermal, or combined) for generating liquid-state Z isomers capable of storing thermal energy. Visible light irradiation induced the selective crystallization of the liquid phase via Z-to-E isomerization, and the latent heat stored in the liquid Z isomers was preserved for longer than 2 weeks unless optically triggered. Up to 92 kJ/mol of thermal energy was stored in the compounds, demonstrating remarkable thermal stability of Z isomers at high temperatures and liquid-phase stability at temperatures below 0 °C.

Arylazo-3,5-dimethylisoxazoles: Azoheteroarene Photoswitches Exhibiting High Z-Isomer Stability, Solid-State Photochromism, and Reversible Light-Induced Phase Transition

Reversibly photoswitchable phenylazo-3,5-dimethylisoxazole and 37 aryl-substituted derivatives were synthesized. Excellent photoswitching ability of these compounds in solution and the solid state was demonstrated. Through kinetics studies by means of NMR spectroscopy, high Z-isomer stability was demonstrated. Interestingly, the majority of the derivatives showed light-induced contrasting color changes in solution and the solid state. Besides, many of the derivatives exhibit partial phase transition upon UV irradiation. The highlight of this class of photoswitches is the reversible light-induced phase transition between solid and liquid phases in the parent compound, which can be used in patterned crystallization. These results show that this new class of azoheteroarene based photoswitches has opportunities to be useful in various domains.

Hierarchical supramolecular hydrogels: Self-assembly by peptides and photo-controlled release: Via host-guest interaction

A hierarchical supramolecular hydrogel was self-assembled from a Fmoc-RGDS tetrapeptide and showed photo-controlled release directed by host-guest interaction. Multiple payloads, including vesicles, were successively released from a single peptide hydrogel.

Structure-Based Rational Design of Novel Inhibitors Against Fructose-1,6-Bisphosphate Aldolase from Candida albicans

Class II fructose-1,6-bisphosphate aldolases (FBA-II) are attractive new targets for the discovery of drugs to combat invasive fungal infection, because they are absent in animals and higher plants. Although several FBA-II inhibitors have been reported, none of these inhibitors exhibit antifungal effect so far. In this study, several novel inhibitors of FBA-II from C. albicans (Ca-FBA-II) with potent antifungal effects were rationally designed by jointly using a specific protocols of molecular docking-based virtual screening, accurate binding-conformation evaluation strategy, synthesis and enzymatic assays. The enzymatic assays reveal that the compounds 3c, 3e-g, 3j and 3k exhibit high inhibitory activity against Ca-FBA-II (IC50 50 value of 2.7 μM. Importantly, the compounds 3f, 3g, and 3l possess not only high inhibitions against Ca-FBA-II, but also moderate antifungal activities against C. glabrata (MIC80 = 4-64 μg/mL). The compounds 3g, 3l, and 3k in combination with fluconazole (8 μg/mL) displayed significantly synergistic antifungal activities (MIC80 0.0625 μg/mL) against resistant Candida strains, which are resistant to azoles drugs. The probable binding modes between 3g and the active site of Ca-FBA-II have been proposed by using the DOX (docking, ONIOM, and XO) strategy. To our knowledge, no FBA-II inhibitors with antifungal activities against wild type and resistant strains from Candida were reported previously. The positive results suggest that the strategy adopted in this study are a promising method for the discovery of novel drugs against azole-resistant fungal pathogens in the future.