1606142-73-7

Basic information

• Product Name: N-benzyl-N-(3-(N-(3-methoxyphenyl)-2,4-dinitrophenylsulfonamido)propyl)-2,4-dinitrobenzenesulfonamide
• Synonyms: N-benzyl-N-(3-(N-(3-methoxyphenyl)-2,4-dinitrophenylsulfonamido)propyl)-2,4-dinitrobenzenesulfonamide
• CAS NO: 1606142-73-7
• Molecular Weight: 730.69
• Mol File: 1606142-73-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-(3-(N-(3-methoxyphenyl)-2,4-dinitrophenylsulfonamido)propyl)-2,4-dinitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-(3-(N-(3-methoxyphenyl)-2,4-dinitrophenylsulfonamido)propyl)-2,4-dinitrobenzenesulfonamide(1606142-73-7)
• EPA Substance Registry System: N-benzyl-N-(3-(N-(3-methoxyphenyl)-2,4-dinitrophenylsulfonamido)propyl)-2,4-dinitrobenzenesulfonamide(1606142-73-7)

Safety Data

• Hazardous Substances Data: 1606142-73-7(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 100-39-0 benzyl bromide 
• 1656-44-6 2,4-dinitrobenzenesulfonyl chloride 

Downstream Products

• 3165-76-2 S-(2,4-Dinitrophenyl)-cystein 
• 7446-09-5 sulfur dioxide 

Relevant articles and documents

Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors

Drug resistant infections are becoming common worldwide and new strategies for drug development are necessary. Here, we report the synthesis and evaluation of 2,4-dinitrophenylsulfonamides, which are donors of sulfur dioxide (SO2), a reactive sulfur species, as methicillin-resistant Staphylococcus aureus (MRSA) inhibitors. N-(3-Methoxyphenyl)-2,4-dinitro-N-(prop-2-yn-1-yl)benzenesulfonamide (5e) was found to have excellent in vitro MRSA inhibitory potency. This compound is cell permeable and treatment of MRSA cells with 5e depleted intracellular thiols and enhanced oxidative species both results consistent with a mechanism involving thiol activation to produce SO2.