1606160-74-0Relevant articles and documents
Room-Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity
Lau, Kai Kiat,Liao, Gang,Ng, Teng Wei,Pan, Hui-Jie,Zhao, Yu
supporting information, p. 11384 - 11389 (2020/06/02)
We report herein an unprecedented highly efficient Guerbet-type reaction at room temperature (catalytic TON up to >6000). This β-alkylation of secondary methyl carbinols with primary alcohols has significant advantage of delivering higher-order secondary alcohols in an economical, redox-neutral fashion. In addition, the first enantioselective Guerbet reaction has also been achieved using a commercially available chiral ruthenium complex to deliver secondary alcohols with moderate yield and up to 92 % ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency.
Stereospecific nickel-catalyzed cross-coupling reactions of alkyl grignard reagents and identification of selective anti-breast-cancer agents
Yonova, Ivelina M.,Johnson, A. George,Osborne, Charlotte A.,Moore, Curtis E.,Morrissette, Naomi S.,Jarvo, Elizabeth R.
supporting information, p. 2422 - 2427 (2014/03/21)
Alkyl Grignard reagents that contain β-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp 3)-C(sp3) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Sev