160632-45-1Relevant academic research and scientific papers
LIPHAGAL ANALOG AND MULTI-TARGETED KINASE INHIBITOR CONTAINING LIPHAGAL OR ANALOG THEREOF
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Paragraph 0166-0168, (2021/07/02)
Provided is an inhibitor for at least one kind of kinase selected from the group consisting of CDK7, CDK4, CDK6, PIM2, TSSK3, MST4, NEK6, MAP3K, MST3, DDR1, SPHK1, CaMK1, AurA, BRK, CaMK4, and PIM1, the inhibitor including as an active ingredient a compound represented by the following general formula (1) or a salt thereof: in the general formula (1), R1, R2, R3, R4, R5, and R6 are as described in Description.
Enantiospecific total syntheses of meroterpenoids (-)-F1839-I and (-)-corallidictyals B and D
Dethe, Dattatraya H.,Dherange, Balu D.,Ali, Saghir,Parsutkar, Mahesh M.
, p. 65 - 68 (2016/12/27)
Enantiospecific total syntheses of spiromeroterpenoid natural products (-)-F1839-I and (-)-corallidictyals B and D were achieved using the environmentally benign and highly atom economical Lewis acid catalysed Friedel-Crafts reaction and a highly regio- and stereoselective spirocyclic C-O bond formation reaction.
Some chemical speculation on the biosynthesis of corallidictyals A-D
Markwell-Heys, Adrian W.,George, Jonathan H.
supporting information, p. 5546 - 5549 (2016/07/06)
The efficient conversion of siphonodictyal B into the spirocyclic natural products corallidictyals A-D has been achieved via oxidative and acid catalyzed cyclizations. The oxidative cyclization of siphonodictyal B occured spontaneously under aerobic oxidation conditions, which suggests that corallidictyals A and B are possibly artefacts of the isolation process. The mechanism of the oxidative cyclization of siphonodictyal B could be described as either an anionic 5-endo-trig cyclization (which is formally disfavoured by Baldwin's rules), or as an electrocyclic reaction, of an ortho-quinone intermediate.
