16064-25-8

Usage

Uses

Used in Pharmaceutical Industry:
7-HYDROXY-1H-QUINAZOLIN-4-ONE is used as a potential drug candidate for its anti-tumor properties, targeting various types of cancer by inhibiting tumor growth and progression. Its anti-inflammatory and antiviral activities also make it a promising agent for the development of new therapeutics to treat inflammation and viral infections.
Used in Organic Synthesis:
In the field of organic synthesis, 7-HYDROXY-1H-QUINAZOLIN-4-ONE serves as a valuable building block for the creation of more complex organic compounds. Its unique structure and functional groups allow for various chemical reactions, facilitating the synthesis of novel compounds with potential applications in different industries.
Used in Drug Development:
7-HYDROXY-1H-QUINAZOLIN-4-ONE is utilized in drug development as a lead compound for the discovery of new pharmaceuticals. Its biological activities and structural features make it an attractive starting point for the design and optimization of new drugs targeting a range of diseases and conditions.

Upstream product

• 446-32-2 4-fluoroanthranilic acid 
• 16499-57-3 7-fluoro-1H-quinazolin-4-one 
• 193002-14-1 7-(benzyloxy)quinazolin-4-ol 
• 619-17-0 4-Nitroanthranilic acid 
• 4294-95-5 4-methoxyanthranilic acid 
• 16064-24-7 7-methoxyquinazoline-4(3H)-one 
• 90004-09-4 7-aminoquinazolin-4-one 

Relevant academic research and scientific papers

Photoinduced homolytic decarboxylative acylation/cyclization of unactivated alkenes with α-keto acid under external oxidant and photocatalyst free conditions: access to quinazolinone derivatives

A novel and green strategy for the synthesis of acylated quinazolinone derivativesviaphoto-induced decarboxylative cascade radical acylation/cyclization of quinazolinone bearing unactivated alkenes has been developed. The protocol provides a novel route to access acyl radicals from α-keto acids through a self-catalyzed energy transfer process. Most importantly, the reaction proceeded smoothly without any external photocatalyst, additive or oxidant, and could be easily scaled-up in flow conditions with sunlight irradiation.

AMINE COMPOUND FOR INHIBITING SSAO / VAP-1 AND USE THEREOF

An amine compound serving as a semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, and an application thereof in medicines that can be used for treating inflammation and/or inflammation related diseases, diabetes and/or a disease related diabetes, psychiatric disorder, ischemic disease, vascular disease, fibrosis, or tissue transplant rejection.

A in the aqueous phase under microwave conditions using halogenated benzamide fast synthesis of quinazoline compounds of the method

The invention discloses a in the aqueous phase under microwave conditions using halogenated benzamide fast synthesis of quinazoline compounds of the method, the use of palladium chloride to serve as the catalyst, in water under microwave heating conditions, neighbouring halogen benzamide with an isocyanate reaction to produce the quinazoline compounds of the method, the invention an environment-friendly, the operation is simple, cheap and safe, efficient process for producing quinazoline compounds of the method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection.

A in ammonia water condition of microwave halo benzoic acid synthesis method of the quinazoline compounds

The invention discloses a in ammonia water condition of microwave halo benzoic acid synthetic quinazoline compounds of the method, the use of palladium chloride to serve as the catalyst, in ammonia water under the microwave heating condition, neighbouring halogen benzoic acid generated by the reaction with the isocyanate of the quinazoline compounds of the method, the invention an environment-friendly, the operation is simple, cheap and safe, efficient process for producing quinazoline compounds of the method. Compared with the prior art, this method not only can be applied to a large number of functional groups, the productive rate is high, few by-products, and the operation is simple, safe, low cost, environmental protection.

Antiviral agents

This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals, as well as nove

QUINAZOLINE DERIVATIVES

The invention concerns a quinazoline derivative of the Formula (I): wherein each of the variables have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.

Antiviral agents

This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammals as well as novel