160666-99-9

Upstream product

• 160666-98-8 (2E,6E)-(4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4,6-dimethyl-octa-2,6-dienal 
• 160666-92-2 (S)-2-benzoyloxypentan-3-one 
• 497-03-0 2-methylbut-2-enal 
• 125948-63-2 (S)-2-hydroxypentan-⁽³⁾-one 
• 93-97-0 benzoic acid anhydride 
• 160666-96-6 (2R,3S,4E)-3-(tert-butyldimethylsilyloxy)-2,4-dimethyl-4-hexenal 
• 160666-95-5 (E)-(2S,3R,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4,6-dimethyl-oct-6-ene-2,3-diol 
• 160666-97-7 (2E,6E)-(4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4,6-dimethyl-octa-2,6-dienoic acid methyl ester 
• 160666-93-3 Benzoic acid (E)-(1S,3R,4S)-4-hydroxy-1,3,5-trimethyl-2-oxo-hept-5-enyl ester 
• 160666-94-4 Benzoic acid (E)-(1S,3R,4S)-4-(tert-butyl-dimethyl-silanyloxy)-1,3,5-trimethyl-2-oxo-hept-5-enyl ester 
• 207680-89-5 (2E,6E)-(4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4,6-dimethyl-octa-2,6-dien-1-ol 

Downstream Products

• 207680-90-8 Benzoic acid (5E,9E)-(1S,3R,4R,7S,8S)-4,8-bis-(tert-butyl-dimethyl-silanyloxy)-1,3,7,9-tetramethyl-2-oxo-undeca-5,9-dienyl ester 

Relevant academic research and scientific papers

Anti Aldol Reactions of Lactate-Derived Ketones: Application to the Total Synthesis of (-)-ACRL Toxin IIIB.

The fungal polyketide derivative (-)-ACRL toxin IIIB (4) has been prepared in 15 steps (21percent yield) from ketone (S)-7 with 88 percent overall ds.The boron-mediated anti aldol reaction of (S)-7 is used twice in the synthesis, controlling the stereoche

Polyketide synthesis using the boron-mediated, anti-aldol reactions of lactate-derived ketones: Total synthesis of (-)-ACRL toxin IIIB

The boron-mediated, anti-selective, aldol reactions of ketone 2 (and related derivatives) proceed with high levels of asymmetric induction, diastereoselectivities of up to 200:1 in favour of the aldol adducts 4 are obtained with achiral aldehydes and reag