160693-21-0

Basic information

• Product Name: 4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97
• Synonyms: 4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97;Benzene, 4-chloro-1-isocyanato-2-phenoxy- (9CI);5-chloro-2-isocyanatophenyl phenyl ether;4-chloro-1-isocyanato-2-phenoxybenzene
• CAS NO: 160693-21-0
• Molecular Formula: C13H8ClNO2
• Molecular Weight: 245.66112
• Product Categories: ISOCYANATE
• Mol File: 160693-21-0.mol

Chemical Properties

• Melting Point: 35-40 °C(lit.)
• Boiling Point: 328.9°C at 760 mmHg
• Flash Point: 152.7°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0.000183mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97(160693-21-0)
• EPA Substance Registry System: 4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97(160693-21-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-42
• Safety Statements: 23-26-36
• WGK Germany: 3
• Hazardous Substances Data: 160693-21-0(Hazardous Substances Data)

Usage

Uses

Used in the Polyurethane Industry:
4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97 is used as a key chemical intermediate for the synthesis of polyurethane materials. Its high reactivity allows for the creation of durable and versatile polyurethane products that can be tailored for various applications.
Safety Precautions:
When working with 4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97, it is crucial to follow proper safety protocols. This includes wearing appropriate protective equipment such as gloves, goggles, and masks to prevent exposure. Additionally, working in a well-ventilated area is essential to minimize the risk of inhaling toxic fumes or vapors. Due to its strong irritant properties, handling 4-CHLORO-2-PHENOXYPHENYL ISOCYANATE 97 with extreme care is necessary to ensure the safety of both individuals and the environment.

InChI:InChI=1/C13H8ClNO2/c14-10-6-7-12(15-9-16)13(8-10)17-11-4-2-1-3-5-11/h1-8H

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 6628-13-3 4-chloro-2-phenoxybenzenamine 

Relevant articles and documents

A new class of inhibitors of secretory phospholipase A2: enolized 1,3-dioxane-4,6-dione-5-carboxamides

Enolized 1,3-dioxane-4,6-dione-5-carboxamides a were identified as a new class of inhibitors of secretory phospholipase A2 from human polymorphonuclear leucocytes (h-PMN PLA2).Among the more than 30 compounds synthesized, the most potent inhibitors (IC50 0.6-10 μM) were found in the series of 2,4-disubstituted phenyl analogues of a.Compound 1a was selected for evaluation of its biological profile.This substance potently inhibited secretory PLA2s from several sources other than human PMNs, with a clear preference for group II over group I PLA2, whereas humancytosolic PLA2 and phospholipase C were not significantly affected.Inhibition of h-PMN PLA2 was calcium-dependent.In intact mammalian cells stimulated in vitro, the release of arachidonic acid and the generation of prostaglandins and leukotrienes were inhibited at concentrations compatible with inhibition of PLA2 as an underlying mechanism.In animal models in vivo (carragheenan oedema, adjuvant arthritis, pertussis pleurisy) 1a showed antiinflammatory activity, although the effect was rather weak compared with standard reference compounds. secretory human PMN phospholipase A2 / enolized 1,3-dioxane-4,6-dione-5-carboxamide inhibitors / cellular eicosanoid synthesis / in vivo antiinflammatory activity / molecular modelling / structure-activity relationship