6628-13-3

Basic information

• Product Name: 4-chloro-2-phenoxyaniline
• CAS NO: 6628-13-3
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.6669
• Mol File: 6628-13-3.mol

Chemical Properties

• Boiling Point: 323.2°C at 760 mmHg
• Flash Point: 149.3°C
• Density: 1.26g/cm³
• Vapor Pressure: 0.000265mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 4-chloro-2-phenoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-phenoxyaniline(6628-13-3)
• EPA Substance Registry System: 4-chloro-2-phenoxyaniline(6628-13-3)

Safety Data

• Hazardous Substances Data: 6628-13-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-chloro-2-phenoxyaniline is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 4-chloro-2-phenoxyaniline serves as an intermediate in the production of agrochemicals. Its role in the synthesis of these chemicals aids in the development of effective pesticides and other agricultural products, enhancing crop protection and yield.

Upstream product

• 56966-63-3 4-chloro-1-nitro-2-phenoxybenzene 
• 7732-18-5 water 
• 7705-08-0 iron(III) chloride 
• 64-19-7 acetic acid 
• 100-67-4 potassium phenolate 
• 108-95-2 phenol 
• 611-06-3 2,4-dichloronitrobenzene 

Downstream Products

• 60287-90-3 N-(4-chloro-2-phenoxy-phenyl)-formamide 
• 37940-99-1 4-Chlor-2-phenoxi-trifluormethansulfonanilid 
• 867252-36-6 N-(4-chloro-2-phenoxy-phenyl)-acetamide 
• 60288-05-3 7-chlorodibenzo[b,f ][1,4]oxazepine 
• 76848-13-0 (4-Chloro-2-phenoxy-phenyl)-imidazolidin-2-ylidene-amine 
• 76839-07-1 (4-Chloro-2-phenoxy-phenyl)-thiourea 

Relevant articles and documents

SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES

The invention relates to substituted acids of formula (I), where T,W,X,Y,Z, R1 and R2 as defined in the claims, as useful pharmaceutical compounds for treating asthma and rhinitis, pharmaceutical compositions containing them, and a processes for their preparation.

Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Since the peripheral benzodiazepine receptor (PBR) has been primarily found as a high-affinity binding site for diazepam in rat kidney, numerous studies of it have been performed. However, the physiological role and functions of PBR have not been fully elucidated. Currently, we presented the pharmacological profile of two high and selective PBR ligands, N-(2,5-dimethoxybenzyl)-N-(4-fluoro-2-phenoxyphenyl)acetamide (7-096, DAA1106) (PBR: IC50=0.28 nM) and N-(4-chloro-2-phenoxyphenyl)-N-(2- isopropoxybenzyl)acetamide (7-099, DAA1097) (PBR: IC50=0.92 nM). The compounds are aryloxyanilide derivatives, and identified with known PBR ligands such as benzodiazepine (1, Ro5-4864), isoquinoline (2, PK11195), imidazopyridine (3, Alpidem), and indole (5, FGIN-1-27) derivatives. The aryloxyanilide derivatives, which have been derived by opening the diazepine ring of 1, are a novel class as PBR ligands and have exhibited high and selective affinity for peripheral benzodiazepine receptors (PBRs). These novel derivatives would be useful for exploring the functions of PBR. In this paper, the design, synthesis and structure-affinity relationships of aryloxyanilide derivatives are described.