160693-23-2Relevant academic research and scientific papers
A facile synthesis of novel and stable phosphorus ylides containing 2-Aryl-1,3-dioxane-4,6-dione
Habibi, Azizollah,Hosseinzadeh, Hedyeh,Aghvami, Seyed Majid
, p. 409 - 420 (2012)
The reaction between dialkyl acetylene dicarboxylate and 2-aryl-1,3-dioxane-4,6-dione derivatives in the presence of triphenylphosphine in ethyl acetate led to stable phosphorus ylides in good yields. These stabilized phosphorus ylides exist as a mixture
Synthesis of fluorenes and their related compounds from biaryls and Meldrum's acid derivatives
Jiang, Zhiyan,Kuninobu, Yoichiro,Sekine, Kohei
supporting information, p. 843 - 846 (2022/02/01)
A new synthetic method for preparing fluorenes from amino group-containing biaryls and Meldrum's acid derivatives was developed. The reaction proceeded without a catalyst and loss of functional groups. The corresponding six- and seven-membered cyclic prod
A new class of inhibitors of secretory phospholipase A2: enolized 1,3-dioxane-4,6-dione-5-carboxamides
Breitenstein, W.,Maerki, F.,Roggo, S.,Wiesenberg, I,Pfeilschifter, J.,et al.
, p. 649 - 658 (2007/10/02)
Enolized 1,3-dioxane-4,6-dione-5-carboxamides a were identified as a new class of inhibitors of secretory phospholipase A2 from human polymorphonuclear leucocytes (h-PMN PLA2).Among the more than 30 compounds synthesized, the most potent inhibitors (IC50 0.6-10 μM) were found in the series of 2,4-disubstituted phenyl analogues of a.Compound 1a was selected for evaluation of its biological profile.This substance potently inhibited secretory PLA2s from several sources other than human PMNs, with a clear preference for group II over group I PLA2, whereas humancytosolic PLA2 and phospholipase C were not significantly affected.Inhibition of h-PMN PLA2 was calcium-dependent.In intact mammalian cells stimulated in vitro, the release of arachidonic acid and the generation of prostaglandins and leukotrienes were inhibited at concentrations compatible with inhibition of PLA2 as an underlying mechanism.In animal models in vivo (carragheenan oedema, adjuvant arthritis, pertussis pleurisy) 1a showed antiinflammatory activity, although the effect was rather weak compared with standard reference compounds. secretory human PMN phospholipase A2 / enolized 1,3-dioxane-4,6-dione-5-carboxamide inhibitors / cellular eicosanoid synthesis / in vivo antiinflammatory activity / molecular modelling / structure-activity relationship
