160695-09-0

Upstream product

• 210887-58-4 (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-one 
• 126971-19-5 (7aS)-7a-methyl-2,3,5,6,7,7a-hexahydro-1H-inden-1-one 
• 210887-74-4 (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one 
• 210887-66-4 (1S,2R,2'S,3S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro[acetic acid-(1H-4b,9-etheno-2,3-dihydroxy-4H-fluorene-4,2'-4'-methyl-isoxazoline)] ester 
• 210887-73-3 (2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one 
• 210887-65-3 (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro[acetic acid-(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)] ester 
• 210887-64-2 (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol 
• 210887-48-2 (2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-one 
• 403621-36-3 C₃₂H₄₀O₅Si 
• 403621-49-8 C₃₂H₄₂O₅Si 
• 403621-50-1 C₂₇H₃₀O₄ 
• 403621-32-9 {1-[(1R,3aS,7aS)-1-(4-Methoxy-phenyl)-7a-methyl-1,4,5,6,7,7a-hexahydro-1,3a-etheno-inden-9-yl]-vinyloxy}-trimethyl-silane 
• 403621-52-3 C₄₁H₄₅NO₆ 
• 403621-35-2 C₃₈H₅₂O₇Si 

Downstream Products

• 166947-38-2 C₂₂H₂₄O₃ 
• 148727-46-2 (5S)-5-ethoxycarbonylmethyl-5',5'-dimethylspirodioxan>-4-one 
• 160695-10-3 C₃₁H₄₀O₆ 
• 163015-44-9 C₂₆H₂₈O₄ 
• 205648-32-4 C₂₂H₂₄O₄ 
• 207616-49-7 C₂₅H₂₈O₄ 
• 360077-82-3 C₂₈H₃₄O₅ 
• 360077-98-1 C₂₅H₃₀O₃ 
• 360077-77-6 C₂₆H₃₀O₄ 
• 360077-84-5 C₃₀H₃₈O₅ 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of a novel series of acylides: 3-O-(3-pyridyl)acetylerythromycin A derivatives

A novel series of acylides, 3-O-(aryl)acetylerythromycin A derivatives, were synthesized and evaluated. These compounds have significant potent antibacterial activity against not only Gram-positive pathogens, including inducibly macrolide-lincosamide-stre

Enantiopure polycycles by sequential cycloadditions

The enolsilyl ether 2, generated from butynone adduct 3, which is easily available from the enantiomerically pure cyclopentadiene 1, proved to be a general building block for polycyclic anellation products to cyclohexenone. After proper adjustment of functional groups in the cycloadducts by means of high pressure Diels-Alder cycloadditions, the thermal retro-process provided routes to various enantiopure alicyclic and heterocyclic target compounds in high yields.

Enantiopure building blocks for marine natural products via differentiation of enantiotopic groups

The group and face-selective cycloaddition of the enantiopure cyclopentadiene 4 to the tyrosine-related spirocylohexadienone 10 provided a high yield of the enantiomencally pure cyclohexadienone 11. Stereoselective transformations at the remaining double bond followed by a thermal retro- process, finally giving rise to the chromophore of the marine agelorin antibiotics isolated from the sponge Agelas oroides Schmidt.

Use of Winterfeldt's template to control the C-2' configuration in the synthesis of strigol-type compounds

A route comprising (i) a cycloaddition reaction of citraconic anhydride with the Winterfeldt auxiliary, (ii) hydride reduction of the cycloadduct, (iii) a (formal) ether formation, and (iv) a cycloreversion reaction allows efficient stereocontrol at C-2' in the synthesis of strigol and its structural analogues.

A predictable enantioselective total synthesis of (+)-clavularin A

Cycloadduct 9 was transformed into vinylsilane 11d in a conjugate addition-alkylation sequence. Epoxidation and subsequent hydrolysis provided the clavularin adduct 14, which on flash vacuum pyrolysis (FVP) gave (+)-clavularin A (1) in 91% yield.

Face-Selective and endo-Selective Cycloadditions with Enantiomerically Pure Cyclopentadienes

A general synthetic route to the enantiopure bicyclic cyclopentadienes (S)-3 and (R)-3 of the hydrindane series, starting from the Hajos-Wiechert ketone 4 or its enantiomer is described.Reasons for the excellent face and endo selectivity of cycloadditions

Enantiopure Didemnenones via Kinetic Resolution

Kinetic resolution in an enantioselective Diels-Alder process provided the starting material for an imporved and simplified approach to all the didemnenones via the lactone 16.