160695-09-0Relevant articles and documents
Synthesis and antibacterial activity of a novel series of acylides: 3-O-(3-pyridyl)acetylerythromycin A derivatives
Tanikawa, Tetsuya,Asaka, Toshifumi,Kashimura, Masato,Suzuki, Keiko,Sugiyama, Hiroyuki,Sato, Masakazu,Kameo, Kazuya,Morimoto, Shigeo,Nishida, Atsushi
, p. 2706 - 2715 (2007/10/03)
A novel series of acylides, 3-O-(aryl)acetylerythromycin A derivatives, were synthesized and evaluated. These compounds have significant potent antibacterial activity against not only Gram-positive pathogens, including inducibly macrolide-lincosamide-stre
Enantiopure building blocks for marine natural products via differentiation of enantiotopic groups
Beil, Winfried,Jones, Peter G.,Nerenz, Frank,Winterfeldt, Ekkehard
, p. 7273 - 7292 (2007/10/03)
The group and face-selective cycloaddition of the enantiopure cyclopentadiene 4 to the tyrosine-related spirocylohexadienone 10 provided a high yield of the enantiomencally pure cyclohexadienone 11. Stereoselective transformations at the remaining double bond followed by a thermal retro- process, finally giving rise to the chromophore of the marine agelorin antibiotics isolated from the sponge Agelas oroides Schmidt.
A predictable enantioselective total synthesis of (+)-clavularin A
Weinmann,Winterfeldt
, p. 1097 - 1101 (2007/10/02)
Cycloadduct 9 was transformed into vinylsilane 11d in a conjugate addition-alkylation sequence. Epoxidation and subsequent hydrolysis provided the clavularin adduct 14, which on flash vacuum pyrolysis (FVP) gave (+)-clavularin A (1) in 91% yield.