210887-48-2

Upstream product

• 210887-62-0 C₃₄H₃₅NO₇ 
• 210887-74-4 (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one 
• 210887-73-3 (2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-carboxylic acid methyl ester-isoxazoline)-1-one 
• 50563-25-2 3-methyl-1-oxa-2-aza-spiro[4.5]deca-2,6,9-trien-8-one 
• 160695-09-0 (S)-3-(4-Methoxy-phenyl)-3a-methyl-4,5,6,7-tetrahydro-3aH-indene 

Downstream Products

• 210887-67-5 (1S,2R,2'S,3S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro[acetic acid-(1H-4b,9-etheno-2,3-diacetoxy-4H-fluorene-4,2'-4'-methyl-isoxazoline)] ester 
• 210887-66-4 (1S,2R,2'S,3S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro[acetic acid-(1H-4b,9-etheno-2,3-dihydroxy-4H-fluorene-4,2'-4'-methyl-isoxazoline)] ester 
• 210887-60-8 C₂₉H₃₅NO₅ 
• 210887-65-3 (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro[acetic acid-(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)] ester 
• 160695-09-0 (S)-3-(4-Methoxy-phenyl)-3a-methyl-4,5,6,7-tetrahydro-3aH-indene 
• 210887-58-4 (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-2,3-dihydroxy-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-one 
• 210887-49-3 (2S,2'S,3R,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-2,3-epoxy-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-one 
• 210887-64-2 (1S,2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-4,4a,4b,5,6,7,8,8a,9,9a-decahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-ol 
• 210887-55-1 (2'S,4aS,4bS,8aS,9R,9aR)-9-(4-methoxyphenyl)-8a-methyl-dodecahydrospiro(1H-4b,9-etheno-4H-fluorene-4,2'-4'-methyl-isoxazoline)-1-one 

Relevant academic research and scientific papers

Biogenetically Patterned Enantioselective Synthesis

Biogenetically orientated enantioselective syntheses of the bicyclic-ether substructure of Azadirachtin and of the spirocyclohexenone building block for the Agelorines are communicated. In the first case the kinetic resolution of a cyclopentenone starting material is exercised in a high pressure Diels-Alder cycloaddition and in the second case the cycloadduct of a prochiral spirocyclohexadienone is used for the differentiation of enantiotopic groups.

Enantiopure building blocks for marine natural products via differentiation of enantiotopic groups

The group and face-selective cycloaddition of the enantiopure cyclopentadiene 4 to the tyrosine-related spirocylohexadienone 10 provided a high yield of the enantiomencally pure cyclohexadienone 11. Stereoselective transformations at the remaining double bond followed by a thermal retro- process, finally giving rise to the chromophore of the marine agelorin antibiotics isolated from the sponge Agelas oroides Schmidt.