1607020-72-3

Upstream product

• 106-49-0 p-toluidine 
• 129-64-6 3,6-endomethylene-1,2,3,6-tetrahydrophthalic anhydride 
• 31448-61-0 2,3-dibromo-3-(4-methoxy-phenyl)-propionic acid 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 6303-59-9 (E)-4-(2-bromo-vinyl)-anisole 
• 72657-49-9 N-(p-methylphenyl)bicyclo[2.2.1]hept-5-ene-endo-2,endo-3-dicarboximide 
• 6303-59-9 (Z)-1-bromo-2-(4-methoxyphenyl)ethene 

Relevant academic research and scientific papers

Palladium(0)-Catalyzed Methylcyclopropanation of Norbornenes with Vinyl Bromides and Mechanism Study

An unusual methylcyclopropanation from [2 + 1] cycloadditions of vinyl bromides to norbornenes catalyzed by Pd(OAc)2/PPh3 in the presence of CH3ONa and CH3OH has been established. A methylcyclopropane subunit was installed by a 3-fold domino procedure involving a key protonation course. Preliminary deuterium-labeling studies revealed that the proton came from methyl of CH3OH and also exposed an additional hydrogen/deuterium exchange process. These two proton-concerned reactions were fully chemoselective.

Palladium(0)-catalyzed methylenecyclopropanation of norbornenes with vinyl bromides

Highly strained methylenecyclopropane derivatives have been achieved via a novel and efficient Pd(0)-catalyzed domino reaction. The formal [2 + 1] cycloaddition reaction of vinyl bromides to norbornenes involves a Heck-type coupling and a C(sp2)-H bond activation.