160721-53-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 160721-42-6 ethyl 4-<3-<(methoxy)methoxy>phenyl>-3-oxobutanoate 
• 160721-40-4 methoxymethyl <3-<(methoxy)methoxy>phenyl>acetate 
• 160721-43-7 ethyl 3,3-ethylenedithio-4-(3-hydroxyphenyl)butanoate 
• 160721-41-5 4-<3-<(methoxy)methoxy>phenyl>acetic acid 
• 621-37-4 m-hydroxyphenylacetic acid 
• 160721-52-8 ethyl 4-<3-(t-butyldimethysilyl)oxy>-3,3-(ethylenedithio)butanoate 

Downstream Products

• 143536-41-8 4-<3-(t-butyldimethysilyl)oxy>-3,3-(ethylenedithio)butanal 

Relevant academic research and scientific papers

Regioselective synthesis of 1,8-dihydroxytetralins through a tandem reduction/intramolecular hydroxyalkylation of 4-(3-hydroxyphenyl)alkanoates

A series of 4-(3-hydroxyphenyl)butanoates 3 has been prepared and transformed into 1,8-dihydroxytetralins of general formula 2 by treatment with 2 equivalents of DIBALH followed by quenching with aqueous NH4Cl. A possible mechanism for this novel totally regioselective intramolecular hydroxyalkylation is suggested and the factors affecting the stability of 1,8-dihydroxytetralins 2 are also discussed.

Tandem Reduction / Intramolecular Hydroxyalkylation of (3-Hydroxyphenyl)alkanoates: a New Regioselective Approach to 1,8-Dihydroxytetralins

4-(3-hydroxyphenyl)-butanoates 4, on treatment with DIBALH, followed by hydrolytic work-up, undergo a novel completely regioselective intramolecular hydroxyalkylation reaction to give 1,8-dihydroxytetralins.The yield of the reaction depends heavily on the structure of starting material, best results being achieved with 3,3-disubstituted butanoates.