160725-46-2Relevant academic research and scientific papers
Synthesis and opioid activities of some naltrexone oxime ethers
Mavunkel, B. J.,Rzeszotarski, W. J.,Kaplita, P. V.,DeHaven-Hudkins, D. L.
, p. 659 - 666 (1994)
A series of alkyl, cycloalkyl, aryl, and aralkyl ethers of naltrexone oxime was prepared.The compounds were examined in binding assays for μ, δ, and κ opioid receptor affinity.In addition, the naltrexone oxime ethers were studied in animal models that measure opioid agonist and antagonist activity.These studies led to the discovery of several compounds, notably phenethyl 3e and phenylpropyl 3f ethers of naltrexone, which have a 10-fold increase in potency at the κ opioid receptor with potent μ and κ agonist properties in vivo.naltrexone / oxime ether / opioid receptor / analgesia / receptor binding / kappa
Stereoelectronics of silyloxybenzoic acids
Varjosaari, Sami E.,Hess, Jeremy P.,Suating, Paolo,Price, John M.,Gilbert, Thomas M.,Adler, Marc J.
supporting information, p. 642 - 645 (2015/03/03)
Synthetic organic chemists generally think of silyl ethers as easier-to-cleave alkyl ethers, frequently neglecting to consider both the unique facets of elemental silicon and the size of commonly used trialkylsilyl protecting groups. In this study, severa
