160744-13-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Thiophenecarboxylic acid, 5-(2-hydroxyethyl)-, methyl ester is used as a chemical intermediate for the synthesis of novel drug molecules, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
This methyl ester derivative may also be utilized in the agrochemical sector for the synthesis of new agrochemical compounds, potentially enhancing crop protection and yield.
Used in Materials Science:
Due to its unique chemical structure, 2-Thiophenecarboxylic acid, 5-(2-hydroxyethyl)-, methyl ester could be employed in materials science for the development of new materials with specific properties, such as conductivity or stability.
Used in Organic Synthesis:
Its reactivity makes it a candidate for use in organic synthesis processes, where it can be a key component in the creation of complex organic molecules for various applications across different industries.

InChI:InChI=1/C8H10O3S/c1-11-8(10)7-3-2-6(12-7)4-5-9/h2-3,9H,4-5H2,1H3

Upstream product

• 67-56-1 methanol 
• 160744-12-7 5-(2-((tert-butyldimethylsilyl)oxy)ethyl)thiophene-2-carboxylic Acid 
• 160744-11-6 2-[2-(tert-butyldimethylsilyloxy)ethyl]thiophene 
• 5402-55-1 2-thiophenethanol 

Relevant academic research and scientific papers

NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND

A novel compound represented by the following general formula (1), or a salt thereof, which has a superior EP4 receptor agonist activity, and a medicament containing the compound or a salt thereof as an active ingredient, which can be used for promotion of osteogenesis, therapeutic treatment and/or promotion of healing of fracture and the like.

Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: Potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition

The design, synthesis, biochemical, and biological evaluation of a novel series of 5-thia-2,6-diamino-4(3H)-oxopyrimidine inhibitors of glycinamide ribonucleotide transformylase (GART) are described. The compounds were designed using the X-ray crystal structure of human GART. The monocyclic 5- thiapyrimidinones were synthesized by coupling an alkyl thiol with 5-bromo- 2,6-diamino-4(3H)-pyrimidinone, 20. The bicyclic compounds were prepared in both racemic and diastereomerically pure forms using two distinct synthetic routes. The compounds were found to have human GART K(i)s ranging from 30 μM to 2 nM. The compounds inhibited the growth of both L1210 and CCRF-CEM cells in culture with potencies down to the low nanomolar range and were found to be selective for the de hove purine biosynthesis pathway. The most potent inhibitors had 2,5-disubstituted thiophene rings attached to the glutamate moiety. Placement of a methyl substituent at the 4-position of the thiophene ring to give compounds 10, 18, and 19 resulted in inhibitors with significantly decreased mFBP affinity.