1607448-87-2

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 14674-35-2 N-(2-nitrobenzylidene)-p-toluenesulfonamide 
• 5443-80-1 3-amino-2-(4'-chlorophenyl)quinoline 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1607449-03-5 N-((2S,3S)-2-(4-chlorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl)-4-methylbenzene-1-sulfonamide 

Relevant academic research and scientific papers

Access to 3-Sulfonamidoquinolines by Gold-Catalyzed Cyclization of 1-(2′-Azidoaryl)propargylsulfonamides through 1,2- N Migration

We describe a gold-catalyzed cyclization of 1-(2′-azidoaryl)propargylsulfonamides for the synthesis of 3-sulfonamidoquinolines, featuring a rare and highly selective 1,2-N migration. The key α-imino gold carbene intermediate is generated through an intram

Synthesis method of polysubstituted 3-sulfonamide quinoline compound

The invention discloses a synthesis method of a polysubstituted 3-sulfonamide quinoline compound, which comprises the following steps: attacking alkynyl by an azide group under the catalysis of gold to form an alpha-imine gold carbene intermediate; and under the action of the alpha-imine intermediate, initiating 1,2-N migration, so as to form the polysubstituted 3-sulfonamide quinoline compound. The synthesis method disclosed by the invention has the advantages of high efficiency, high universality to substrates and the like.

Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of quinolin-3-amines

A chiral phosphoric acid catalyzed asymmetric transfer hydrogenation of aromatic amines, quinolin-3-amines, was successfully developed with up to 99% ee. To supplement our previous work on the Ir-catalyzed asymmetric hydrogenation of 2-alkyl substituted q