1607462-63-4Relevant academic research and scientific papers
Biomimetic asymmetric total syntheses of spirooliganones A and B
Song, Liyan,Yao, Hongliang,Tong, Rongbiao
, p. 3740 - 3743 (2014)
Biomimetic total syntheses of potent antiviral spirooliganones A and B were achieved with 3% and 2% yield, respectively, in 12 steps from commercially available materials. The synthetic strategy was inspired primarily by the biogenetic hypothesis and was enabled by two independent cascade events: (i) an unprecedented reaction involving aromatic Claisen rearrangement/o-quinone methide formation/hetero-Diels-Alder cycloaddition to construct the tetracyclic framework and (ii) phenol oxidative dearomatization/spirocyclization to build the spiro-fused cyclohexadienone/tetrahydrofuran moiety.
