160776-14-7Relevant academic research and scientific papers
Synthesis of chemically and functionally diverse scaffolds from pentaerythritol
Hanessian, Stephen,Prabhanjan, Hubli,Qiu, Dongxu,Nambiar, Sudhir
, p. 1731 - 1737 (2007/10/03)
Pentaerythritol (2,2-bis-hydroxymethyl-propane-1,3-diol) was converted into a series of mono-, di-, and trisubstituted derivatives, comprising allyl ethers and amino-alkyl ethers, by systematic chemical manipulation of the hydroxy groups. The remaining hydroxymethyl group in the case of the trisubstituted analog was functionalized with ether groups bearing terminal ω-carboxyl or ω-alkene groups. These derivatives are versatile templates and scaffolds for single, double, or triple substitution with appropriate ligands forming amides and esters, and allowing the attachment of the ω-alkene or ω-carboxyl group to solid support for combinatorial chemistry.
Synthesis of novel mimetics of the sialyl Lewis X determinant
Toepfer,Toepfer, Alexander,Kretzschmar,Kretzschmar, Gerhard,Bartnik,Bartnik, Eckart
, p. 9161 - 9164 (2007/10/02)
Mimetics of the sialyl Lewis-X determinant in which at least one sugar domain is simulated by a di-, tri- or tetraalcohol unit have been synthesized. The inhibitory potency of these compounds for E- and P-selectin mediated cell adhesion has been evaluated in cell culture assays. The receptor binding affinity of the best of these mimetics was slightly higher than that of the natural oligosaccharide ligand sialyl Lewis X.
