1607788-53-3Relevant academic research and scientific papers
Labeling Studies Clarify the Committed Step in Bacterial Gibberellin Biosynthesis
Nett, Ryan S.,Dickschat, Jeroen S.,Peters, Reuben J.
, p. 5974 - 5977 (2016)
Bacteria have evolved gibberellin phytohormone biosynthesis independently of plants and fungi. Through 13C-labeling and NMR analysis, the mechanistically unusual B ring contraction catalyzed by a cytochrome P450 (CYP114), which is the committed step in gibberellin biosynthesis, was shown to occur via oxidative extrusion of carbon-7 from ent-kaurenoic acid in bacteria. This is identical to the convergently evolved chemical transformation in plants and fungi, suggesting a common semipinacol rearrangement mechanism potentially guided by carbon-4α carboxylate proximity.
Labelling studies on the biosynthesis of terpenes in Fusarium fujikuroi
Citron, Christian A.,Brock, Nelson L.,Tudzynski, Bettina,Dickschat, Jeroen S.
, p. 5224 - 5226 (2014)
Synthetic [2-13C]mevalonolactone was fed to the gibberellin producer Fusarium fujikuroi and its incorporation into four known terpenoids was investigated by 13C NMR analysis of crude culture extracts. The experiments gave detailed in
