1607820-06-3

Upstream product

• 108-59-8 malonic acid dimethyl ester 

Relevant academic research and scientific papers

A d -Camphor-Based Schiff Base as a Highly Efficient N,P Ligand for Enantioselective Palladium-Catalyzed Allylic Substitutions

New Schiff bases derived from chiral d-camphor were determined to be effective phosphine ligands for the asymmetric palladium-catalyzed allylic alkylation of activated methylene compounds, the allylic etherification of alcohols, and the allylic amination of primary amines or secondary amines, in which the corresponding products with various functional groups were achieved in good yields with excellent enantioselectivities (up to >99 % ee). Remarkably, the palladium catalyst derived from Schiff base L2 afforded the highest level of enantioselectivity reported to date for allylic substitution reactions, including allylic etherification and allylic amination, which revealed the privileged role of d-camphor-derived Schiff bases in palladium-catalyzed allylic substitution reactions.

Chiral (E)-2-(1, 3-diaryl allyl) dimethyl malonate compounds and preparation method thereof

The invention provides chiral (E)-2-(1, 3-diaryl allyl) dimethyl malonate compounds and a preparation method thereof, the method adopts a chiral Pd catalyst to catalyze asymmetric substitution reaction of (E)-1, 3-diaryl allyl acetate compound and dimethy

Synthesis of highly rigid phosphine-oxazoline ligands for palladium-catalyzed asymmetric allylic alkylation

A highly rigid spiro phosphine-oxazoline ligand skeleton with a spirocarbon stereogenic center was developed from 7-bromo-1-indanone. The catalytic performance of the ligand was demonstrated in palladium-catalyzed asymmetric allylic alkylation. Under opti

Synthesis of chiral S,N-thioimidazoline ligands for palladium-catalyzed asymmetric allylic alkylations

A series of chiral S,N-thioimidazoline ligands have been synthesized using 2-bromobenzoic acid or 1-bromo-2-naphthoic acid as starting materials. The obtained ligands were evaluated in the Pd-catalyzed asymmetric allylic alkylations and exhibited high catalytic efficiency: yields of up to 94% and enantioselectivities of up to 86% were achieved under the optimized conditions.

Highly enantioselective alkylation of allyl acetates using tartrate-derived bioxazoline ligands

Tartrate-derived bioxazoline ligands, which form a five-membered chelate ring with metals, were evaluated for use in the asymmetric allylic alkylation (AAA) reactions of various symmetrical and unsymmetrical allyl acetates. Excellent enantioselectivities

Highly Enantioselective Alkylation of Allyl Acetates Using Tartrate-Derived Bioxazoline Ligands

Tartrate-derived bioxazoline ligands, which form a five-membered chelate ring with metals, were evaluated for use in the asymmetric allylic alkylation (AAA) reactions of various symmetrical and unsymmetrical allyl acetates. Excellent enantioselectivities were achieved by using both symmetrical and unsymmetrical allyl acetates. Palladium(II)-catalyzed asymmetric allylic alkylation reactions of various symmetrical and unsymmetrical allyl acetates were achieved by using bioxazoline ligands, which were derived from tartaric acid, to give products with excellent enantioselectivity.