1607820-58-5

Upstream product

• 1607820-48-3 4-ethoxy-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]-triazin-5-yl)benzene-1-sulfonyl chloride 
• 1607820-47-2 3-(2-ethoxyphenyl)-1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]-triazine 
• 213211-69-9 (2-ethoxyphenyl)boronic acid 
• 682319-80-8 1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine 

Relevant academic research and scientific papers

Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity

A series of sildenafil analogues and aniline substituted pyrazolo[4,3-e][1,2,4]triazine sulfonamides were prepared and evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors and for their anticancer activity against two human breast cancer cell lines (MCF-7, MDA-MB-231). The new compounds were ineffective as CA I inhibitors, poorly inhibited CA II, but were more effective against the tumor-associated isoforms CA IX and XII, with some compounds acting as low nanomolar inhibitors. Evaluation of the cytotoxicity by using an MTT assay, the inhibition of [3H]thymidine incorporation into DNA as well as collagen synthesis inhibition, demonstrated that these sulfonamides exhibit cytotoxic effects on breast cancer cell lines ex vivo.