1607837-98-8

Basic information

• Product Name: 5-bromo-3,4-dichloropyridin-2-amine
• Synonyms: 5-bromo-3,4-dichloropyridin-2-amine;5-Bromo-3,4-dichloro-pyridin-2-ylamine
• CAS NO: 1607837-98-8
• Molecular Formula: C5H3BrCl2N2
• Molecular Weight: 241.90072
• EINECS: -0
• Mol File: 1607837-98-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 273.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.934±0.06 g/cm3(Predicted)
• PKA: 0.86±0.50(Predicted)
• CAS DataBase Reference: 5-bromo-3,4-dichloropyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3,4-dichloropyridin-2-amine(1607837-98-8)
• EPA Substance Registry System: 5-bromo-3,4-dichloropyridin-2-amine(1607837-98-8)

Safety Data

• Hazardous Substances Data: 1607837-98-8(Hazardous Substances Data)

Upstream product

• 942947-94-6 5-bromo-4-chloro-pyridin-2-ylamine 
• 19798-80-2 2-Amino-4-chloropyridine 

Downstream Products

• 1607838-03-8 5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine 
• 1607837-28-4 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-3-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 
• 1607838-28-7 8-[2-[bis-(4-methoxybenzyl)amino]-3-chloro-5-(2-ethyl-1,1-dioxo-2,3-dihydro-1H-benzo[d]isothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one 
• 1607837-22-8 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 
• 1607837-31-9 8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 
• 1607838-04-9 8-(2-(bis(4-methoxybenzyl)amino)-5-bromo-3-chloropyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione 
• 1607838-05-0 8-(2-(bis(4-methoxybenzyl)amino)-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione 
• 1607837-44-4 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione 
• 1607838-06-1 8-{2-[bis-(4-methoxybenzyl)amino]-5-bromo-3-chloropyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-one 
• 1607837-17-1 1'-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)spiro[indoline-3,4'-piperidin]-2-one 
• 1607837-36-4 1-(2-amino-3-chloro-5-(4-(4-methylpiperazin-1-yl)phenyl)pyridin-4-yl)piperidine-4-carbonitrile 
• 1607837-46-6 9-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-1,4,9-triazaspiro[5.5]undecan-5-one 
• 1607837-73-9 8-(2-amino-3-chloro-5-{4-[1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl]phenyl}pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one 
• 1607837-16-0 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one 

Relevant articles and documents

Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation

CDK8 is deregulated in multiple types of human cancer and is viewed as a therapeutic target for the treatment of the disease. Accordingly, the search for small-molecule inhibitors of CDK8 is being intensified. Capitalising on our initial discovery of AU1-100, a potent CDK8 inhibitor yet with a limited degree of kinase selectivity, a structure-based optimisation was carried out, with a series of new multi-substituted pyridines rationally designed, chemically prepared and biologically evaluated. Such endeavour has culminated in the identification of 42, a more potent CDK8 inhibitor with superior kinomic selectivity and oral bioavailability. The mechanism underlying the anti-proliferative effect of 42 on MV4-11 cells was studied, revealing that the compound arrested the G1 cell cycle and triggered apoptosis. The low risk of hepato- and cardio-toxicity of 42 was estimated. These findings merit further investigation of 42 as a targeted cancer therapeutic.

2-AMINOPYRIDINE COMPOUNDS

The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.