1608092-47-2Relevant academic research and scientific papers
A Metal-Free Oxidative Cross-Dehydrogenative Coupling of N-Aryl Tetrahydroisoquinolines and 2-Methylazaarenes Using a Recyclable Oxoammonium Salt as Oxidant in Aqueous Media
Fang, Li,Li, Zhenhua,Jiang, Zhijiang,Tan, Zhiyong,Xie, Yuanyuan
, p. 3559 - 3567 (2016/07/28)
A metal-free oxidative cross-dehydrogenative coupling of N-aryl tetrahydroisoquinolines and 2-methylazaarenes in water under mild conditions has been developed. 4-Acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate was employed as a mild oxidant that can be recovered and reused directly. The reaction proceeds through formation of an iminium ion in situ followed by condensation with various nucleophiles, providing the desired products in moderate to good yields.
Preparation method adopting copper complex to catalyze coupling reaction of 2-methylquinoline and tetrahydroisoquinoline under visible light
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Paragraph 0014, (2016/10/07)
The invention relates to a method for adopting a 2,9-dimethyl-4,7-diphenyl-1,10-o-phenanthroline carborane bis (diphenylphosphine) copper (i) complex to catalyze a dehydrogenative coupling reaction of a 2-methylquinoline compound and a tetrahydroisoquinoline compound under visible light. According to the preparation method, the 2,9-dimethyl-4,7-diphenyl-1,10-o-phenanthroline carborane bis (diphenylphosphine) copper (i) complex as a photocatalyst, corresponding 2-methylquinoline, tetrahydroisoquinoline and m-toluic acid are mixed in the mole ratio being 0.015:2:1:3, solvents acetonitrile and methyl alcohol are added, acetonitrile and methyl alcohol are mixed in the volume ratio being 1:1, a reaction system is full of oxygen, 3.5w white-light LED lamp strip is placed in a position 2 cm away from a reaction flask, the solvents are evacuated from the reaction system after 35 h, and a corresponding product is obtained through silica-gel column chromatography separation. The method has the benefits that the visible light is used for reaction catalysis, and environmental protection and low carbon are realized.
C(sp3)-C(sp3) bond formation via copper/ Bronsted acid co-catalyzed C(sp3)-H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes
Wang, Fang-Fang,Luo, Cui-Ping,Deng, Guojun,Yang, Luo
supporting information, p. 2428 - 2431 (2014/05/06)
A copper/Bronsted acid dual-catalyst promoted oxidative cross-dehydrogenative-coupling of alkylazaarenes and tertiary amines for C(sp3)-C(sp3) bond formation was developed. This method uses dioxygen as the terminal oxidant under mild reaction conditions and would provide a convenient benzylic C-H transformation of alkylazaarenes to biologically active pharmaceutics. the Partner Organisations 2014.
