1608092-53-0

Upstream product

• 91875-31-9 2-methyl-6-phenylquinoline 
• 3340-78-1 2-phenyl-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Preparation method adopting copper complex to catalyze coupling reaction of 2-methylquinoline and tetrahydroisoquinoline under visible light

The invention relates to a method for adopting a 2,9-dimethyl-4,7-diphenyl-1,10-o-phenanthroline carborane bis (diphenylphosphine) copper (i) complex to catalyze a dehydrogenative coupling reaction of a 2-methylquinoline compound and a tetrahydroisoquinoline compound under visible light. According to the preparation method, the 2,9-dimethyl-4,7-diphenyl-1,10-o-phenanthroline carborane bis (diphenylphosphine) copper (i) complex as a photocatalyst, corresponding 2-methylquinoline, tetrahydroisoquinoline and m-toluic acid are mixed in the mole ratio being 0.015:2:1:3, solvents acetonitrile and methyl alcohol are added, acetonitrile and methyl alcohol are mixed in the volume ratio being 1:1, a reaction system is full of oxygen, 3.5w white-light LED lamp strip is placed in a position 2 cm away from a reaction flask, the solvents are evacuated from the reaction system after 35 h, and a corresponding product is obtained through silica-gel column chromatography separation. The method has the benefits that the visible light is used for reaction catalysis, and environmental protection and low carbon are realized.

C(sp3)-C(sp3) bond formation via copper/ Bronsted acid co-catalyzed C(sp3)-H bond oxidative cross-dehydrogenative-coupling (CDC) of azaarenes

A copper/Bronsted acid dual-catalyst promoted oxidative cross-dehydrogenative-coupling of alkylazaarenes and tertiary amines for C(sp3)-C(sp3) bond formation was developed. This method uses dioxygen as the terminal oxidant under mild reaction conditions and would provide a convenient benzylic C-H transformation of alkylazaarenes to biologically active pharmaceutics. the Partner Organisations 2014.