1608127-97-4

Basic information

• Product Name: C₂₃H₂₄N₂O₃S
• CAS NO: 1608127-97-4
• Molecular Weight: 408.521
• Mol File: 1608127-97-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₄N₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₄N₂O₃S(1608127-97-4)
• EPA Substance Registry System: C₂₃H₂₄N₂O₃S(1608127-97-4)

Safety Data

• Hazardous Substances Data: 1608127-97-4(Hazardous Substances Data)

Upstream product

• 7797-81-1 N-hydroxy-1,8-naphthalenedicarboximide 
• 1830-56-4 1-ethylbenzo[cd]indole-2(1H)-one 
• 130-00-7 1,8-naphtholactam 
• 5551-72-4 1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl 4-methylbenzenesulfonate 
• 5369-19-7 3-tert-butylaniline 
• 32103-15-4 1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonyl chloride 
• 81-84-5 1,8-Naphthalic anhydride 

Relevant articles and documents

Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

Retinoic acid receptor-related orphan receptor γ (RORγ), a member of the nuclear hormone receptor superfamily, is a promising therapeutic target for treating Th17-mediated autoimmune diseases. We performed structure-based virtual screening targeting the RORγ ligand-binding domain. Among the tested compounds, s4 demonstrated RORγ antagonistic activities with micromolar IC50 values in both an AlphaScreen assay (20.27 μM) and a cell-based reporter gene assay (11.84 μM). Optimization of the s4 compound led to the identification of compounds 7j, 8c, 8k, and 8p, all of which displayed significantly enhanced RORγ inhibition with IC 50 values of 40-140 nM. These results represent a promising starting point for developing potent small molecule RORγ inhibitors.