1830-56-4Relevant articles and documents
The effects of novel heme oxygenase inhibitors on the growth of Pseudomonas aeruginosa
Zhao, Jingming,Liang, Dongdong,Robinson, Elizabeth,Xue, Fengtian
, p. 64 - 67 (2019)
Objectives: This study was aimed to develop small molecule inhibitors of the P. aeruginosa heme oxygenase (pa-HemO) as potential treatment of infections caused by P. aeruginosa. Methods: New compounds were designed based on the crystal structure of pa-HemO. The binding affinities (KD) were determined using intrinsic fluorescence quenching assays. The anti-microbial effects of the new compounds was evaluated by minimal inhibitory concentration 50% (MIC50). Results: Eleven compounds were synthesized as potential pa-HemO inhibitors. New compounds demonstrated KD values ranging from 1.5 to 180 μM, and MIC50 values ranging from 26 to 260 μg/mL. The compounds had good affinity with HemO and promising anti-microbial effects on P. aeruginosa. Conclusions: The new inhibitors described herein can inhibit the growth of P. aeruginosa via the inhibition of pa-HemO. There may be broad prospects for HemO inhibitors to treat P. aeruginosa related infections.
NTR-1 response type fluorescent probe based on benzoindole as well as preparation method and application thereof
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Paragraph 0036-0038, (2021/04/10)
The invention discloses an NTR-1 response type fluorescent probe based on benzoindole as well as a preparation method and application of the NTR-1 response type fluorescent probe. The structure of the NTR-1 response type fluorescent probe is as defined in the specification. The method comprises the following steps: subjecting p-hydroxybenzaldehyde to reacting with p-nitrobenzyl bromide to synthesize a stable intermediate NFP-1-M connected through ether bonds, and condensing 1-ethyl-2-methylbenzo[cd]indole-1-chloride with the intermediate NFP-1-M to generate the probe NFP-1. The probe can be used for measuring the hypoxia degree of a cell, and is beneficial to early diagnosis of tumors and the like.
NEAR INFRARED (NIR) LASER PROCESSING OF RESIN BASED ARTICLES
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Paragraph 0115; 0125-0127, (2020/02/06)
A near infrared (NIR) laser processable resin based article comprising a specific optothermal converting. The specific optothermal converting has an improved thermal stability and therefore renders the preparation of the resin based article more reliable.