16082-59-0

Basic information

• Product Name: 8-(4-benzenesulfonylamino)quinoline
• Synonyms: 8-(4-benzenesulfonylamino)quinoline;N-(8-quinolinyl)benzenesulfonamide;N-(quinolin-8-yl)benzenesulfonamide
• CAS NO: 16082-59-0
• Molecular Formula: C₁₅H₁₂N₂O₂S
• Molecular Weight: 284.33298
• Mol File: 16082-59-0.mol
• Article Data: 25

Chemical Properties

• Melting Point: 132.5-133 °C
• Boiling Point: 486.2°Cat760mmHg
• Flash Point: 247.9°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 1.32E-09mmHg at 25°C
• Refractive Index: 1.696
• PKA: 7.49±0.30(Predicted)
• CAS DataBase Reference: 8-(4-benzenesulfonylamino)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-benzenesulfonylamino)quinoline(16082-59-0)
• EPA Substance Registry System: 8-(4-benzenesulfonylamino)quinoline(16082-59-0)

Safety Data

• Hazardous Substances Data: 16082-59-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H12N2O2S/c18-20(19,13-8-2-1-3-9-13)17-14-10-4-6-12-7-5-11-16-15(12)14/h1-11,17H

Upstream product

• 1014006-07-5 2-bromo-N-(quinolin-8-yl)benzenesulfonamide 
• 607-35-2 8-nitroquinoline 
• 88-74-4 2-nitro-aniline 
• 578-66-5 8-amino quinoline 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 461054-22-8 Ni(C₉H₆NNSO₂C₆H₅)2(H₂O)(CH₃OH) 
• 524679-24-1 bis[N-(quinolin-8-yl)benzenesulfonamidato-κ²N,N′]copper(II) 

Relevant articles and documents

Sulfoxylate Anion Radical-Induced Aryl Radical Generation and Intramolecular Arylation for the Synthesis of Biarylsultams

Aryl radical generation from the corresponding aryl halides using an electron donor and subsequent intramolecular cyclization with arenes could be an important advancement in contemporary biaryl synthesis. A green and practically useful synthetic protocol to access diverse six- and seven-membered biarylsultams especially with a free NH group including demonstration of a gram-scale synthesis is reported herein. The sulfoxylate anion radical (SO2-?), generated in situ from the reagents rongalite or sodium dithionite (Na2S2O4), was found to be the key single electron transfer agent forming aryl radicals from aryl halides, which upon intramolecular arylation gives biarylsultams with good to excellent yields. The approach features generation of aryl radicals that remained underexplored, use of a cheap and readily available industrial reagents, and transition metal-free, mild, and green reaction conditions.

Non-emissive RuII Polypyridyl Complexes as Efficient and Selective Photosensitizers for the Photooxidation of Benzylamines

Five new RuII polypyridyl complexes bearing N-(arylsulfonyl)-8-amidoquinolate ligands and three of their biscyclometalated IrIII congeners have been prepared and employed as photocatalysts (PCs) in the photooxidation of benzylamines with O2. In particular, the new RuII complexes do not exhibit photoluminescence, rather they harvest visible light efficiently and are very stable in solution under irradiation with blue light. Their non-emissive behavior has been related to the low electrochemical energy gaps and rationalized on the basis of theoretical calculations (DFT analysis) that predict low S0←T1 energy values. Moreover, the RuII complexes, despite being non-emissive, display excellent activities in the selective photocatalytic transformation of benzylamines into the corresponding imines. The presence of an electron-withdrawing group (-CF3) on the arene ring of the N-(arylsulfonyl)-8-amidoquinolate ligand improves the photocatalytic activity of the corresponding photocatalyst. Furthermore, all the experimental evidence, including transient absorption spectroscopy measurements suggest that singlet oxygen is the actual oxidant. The IrIII analogues are considerably more photosensitive and consequently less efficient photosensitizers (PSs).

NEUROPROTECTIVE QUINOLINE SULFONAMIDES

Disclosed herein are methods and compositions comprising compounds capable of activating and increasing protein SUMOylation. Disclosed herein are methods and compositions comprising compounds capable of showing neuroprotective and cytoprotective effects w