160823-80-3

Upstream product

• 74635-18-0 N-benzylmethylene nitrone 
• 134107-65-6 (3R,7aS)-3-phenyl-3,7a-dihydro-1H-pyrrolo[1,2-c]oxazol-5-one 

Downstream Products

• 849402-57-9 (2R,3S,4S)-1-benzyl-4-benzylaminomethyl-3-hydroxy-2-hydroxymethylpyrrolidine 
• 849402-63-7 (3S,4S,5R)-1-benzyl-5-(N-benzyl-N-tert-butyloxycarbonylamino)methyl-3,4-dihydroxypiperidine 
• 849402-62-6 (2R,3S,4R)-1-benzyl-4-(N-benzyl-N-tert-butyloxycarbonylamino)methyl-3-hydroxy-2-hydroxymethylpyrrolidine 
• 849402-58-0 (3S,4S,5S)-1-benzyl-5-benzylaminomethyl-3,4-dihydroxypiperidine 
• 910541-82-1 (2R,3S,4S)-3-acetoxy-1-acetyl-4-(benzylacetamidomethyl)-2-(1-ethoxyethoxymethyl)pyrrolidine 
• 910541-84-3 (2S,3S,4S)-3-acetoxy-1-acetyl-4-(benzylacetamidomethyl)pyrrolidine-2-carboxylic acid 
• 910541-83-2 (2R,3S,4S)-3-acetoxy-1-acetyl-4-(benzylacetamidomethyl)-2-hydroxymethylpyrrolidine 
• 910541-80-9 (3aR,6R,6aS)-2-benzyl-6-(1-ethoxyethoxymethyl)tetrahydro-2H-pyrrolo[3,4-d]osoxazol-4(5H)-one 
• 910541-81-0 (2R,3S,4S)-4-(benzylaminomethyl)-2-(1-ethoxyethoxymethyl)pyrrolidin-3-ol 
• 162826-84-8 (4R,7R,8S)-2-benzyl-7-hydroxymethyl-1-oxa-2,6-diazabicyclo<3.3.0>octane-5-one 

Relevant academic research and scientific papers

1,3-Dipolar cycloadditions of nitrones to α,β-unsaturated γ-lactams derived from (S)-pyroglutaminol

α,β-unsaturated γ-lactams undergo regio- and stereoselective 1,3-dipolar cycloadditions with N-benzyl and N-methyl nitrones and can act as acceptors in conjugate addition of N-methylhydroxylamine. These reactions give access to highly functionalized pyrrolidones.