1,3-Dipolar cycloadditions of nitrones to α,β-unsaturated γ-lactams derived from (S)-pyroglutaminol

Article abstract of DOI:10.1016/0040-4020(95)00100-M

α,β-unsaturated γ-lactams undergo regio- and stereoselective 1,3-dipolar cycloadditions with N-benzyl and N-methyl nitrones and can act as acceptors in conjugate addition of N-methylhydroxylamine. These reactions give access to highly functionalized pyrrolidones.