160845-31-8Relevant academic research and scientific papers
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2 H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents
Banerjee, Anupam G.,Das, Nirupam,Shengule, Sushant A.,Srivastava, Radhey Shyam,Shrivastava, Sushant Kumar
, p. 81 - 95 (2015)
A series of triazin-3(2H)-one derivatives bearing 1,3,4-oxadiazole (4a-4o) were synthesized, characterized and evaluated for anti-inflammatory and analgesic activities. Preliminary in vitro anti-inflammatory activity was assessed using an albumin denatura
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach
Banerjee, Anupam G.,Das, Nirupam,Shengule, Sushant A.,Sharma, Piyoosh A.,Srivastava, Radhey Shyam,Shrivastava, Sushant Kumar
, p. 102 - 120 (2016)
A series of novel hybrids comprising of 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole tethered to 5,6-diphenyl-1,2,4-triazin-3(2H)-one were designed, synthesised and evaluated as COX-2 inhibitors for the treatment of inflammation. The synthesised hybrids were characterised using FT-IR, 1H NMR, 13C NMR, elemental (C,H,N) analyses and assessed for their anti-inflammatory potential by in vitro albumin denaturation assay. Compounds exhibiting activity comparable to indomethacin and celecoxib were further evaluated for in vivo anti-inflammatory activity. Oral administration of promising compounds 3c–3e and 4c–4e did not evoke significant gastric, hepatic and renal toxicity in rats. These potential compounds exhibited reduced malondialdehyde (MDA) content on the gastric mucosa suggesting their protective effects by inhibition of lipid peroxidation. Based on the outcome of in vitro COX assay, compounds 3c–3e and 4c–4e (IC50 0.60–1.11 μM) elicited an interesting profile as competitive selective COX-2 inhibitors. Further, selected compounds 3e and 4c were found devoid of cardiotoxicity post evaluation on myocardial infarcted rats. The in silico binding mode of the potential compounds into the COX-2 active site through docking and molecular dynamics exemplified their consensual interaction and subsequent COX-2 inhibition with significant implications for structure-based drug design.
Synthesis and antimicrobial activity of some nitrogen heterobicyclic systems: Part III
El-Mariah,Saad,Allimony,Abdel-Rahman
, p. 36 - 41 (2007/10/03)
In search for a newer antimicrobial agents, some new nitrogen heterobicyclic systems 3-20 have been synthesized via condensation of the corresponding acetic acid hydrazide 2 with some oxygen compounds. The structures of these target compounds have been elucidated by elemental analysis and spectral data (IR, 1H NMR and mass). The biocidal activity of the products have also been determined using gentamycin as standard antibiotic. Some compounds show equivalent activity to that of gentamycin towards S. marcesceus.
