4512-00-9

Basic information

• Product Name: 3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE
• Synonyms: 4-triazin-3(2h)-one,5,6-diphenyl-2;5,6-diphenyl-as-triazin-3(2h)-one;5,6-diphenyl-as-triazin-3-o;5,6-diphenyl-as-triazin-3-ol;ai3-15232;3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE;5,6-DIPHENYL-3-HYDROXY-1,2,4-TRIAZINE;5,6-DIPHENYL-1,2,4-TRIAZIN-3-OL
• CAS NO: 4512-00-9
• Molecular Formula: C₁₅H₁₁N₃O
• Molecular Weight: 249.27
• EINECS: 224-833-6
• Mol File: 4512-00-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 224-225°C
• Boiling Point: 392.37°C (rough estimate)
• Flash Point: 241.9°C
• Appearance: /
• Density: 1.1469 (rough estimate)
• Vapor Pressure: 1.07E-09mmHg at 25°C
• Refractive Index: 1.5700 (estimate)
• CAS DataBase Reference: 3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE(4512-00-9)
• EPA Substance Registry System: 3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE(4512-00-9)

Safety Data

• Statements: 22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• RTECS: XZ2852000
• HazardClass: IRRITANT
• Hazardous Substances Data: 4512-00-9(Hazardous Substances Data)

Usage

General Description

3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE is a chemical compound with the molecular formula C18H13N3O. It is a triazine derivative that contains hydroxyl and phenyl functional groups. 3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE is used in various industrial applications, including as a building block for the synthesis of organic compounds and as a precursor for the production of pharmaceuticals and agrochemicals. It may also have potential applications in the field of materials science and as a research tool in chemical and biological studies. The exact properties and uses of 3-HYDROXY-5,6-DIPHENYL-1,2,4-TRIAZINE may vary depending on its specific chemical structure and purity.

InChI:InChI=1/C15H11N3O/c19-15-16-13(11-7-3-1-4-8-11)14(17-18-15)12-9-5-2-6-10-12/h1-10H,(H,16,18,19)

Upstream product

• 7478-16-2 3-methoxy-5,6-diphenyl-[1,2,4]triazine 
• 34177-11-2 3-chloro-5,6-diphenyl-1,2,4-triazine 
• 31283-03-1 6-methoxy-1,6-diphenyl-4-oxo-3,4,5,6-tetrahydro-2,3,5-triazine 
• 134-81-6 benzil 
• 4426-72-6 hydrazine carboxamide 
• 3540-90-7 benzil mono-semicarbazone 
• 563-41-7 semicarbazide hydrochloride 
• 13163-06-9 3-phenoxy-5,6-diphenyl-[1,2,4]triazine 
• 69466-94-0 5,6-diphenyl-3-p-tolyloxy-[1,2,4]triazine 
• 84346-96-3 3-dichloromethyl-5,6-diphenyl-as-triazine 
• 84346-95-2 3-trichloromethyl-5,6-diphenyl-as-triazine 
• 108306-13-4 5,6-diphenyl-tetrahydro-[1,2,4]triazin-3-one 
• 37469-24-2 5,6-diphenyl-4H-[1,2,4] triazine-3-thione 
• 24108-37-0 3-methyl-5,6-diphenyl-1,2,4-triazine 

Downstream Products

• 18510-97-9 2-methyl-5,6-diphenyl-1,2,4-triazin-3(2H)-one 
• 21134-91-8 5,6-diphenyl-1,2,4-triazine 
• 34177-11-2 3-chloro-5,6-diphenyl-1,2,4-triazine 
• 13163-00-3 4,5-dihydro-5,6-diphenyl-as-triazin-3-one 
• 135591-06-9 8-(3-Oxo-5,6-diphenyl-3H-[1,2,4]triazin-2-yl)-octanoic acid methyl ester 
• 135591-08-1 methyl <3-<2-(2,3-dihydro-3-oxo-5,6-diphenyl-1,2,4-triazin-2-yl)ethyl>phenoxy>acetate 
• 87121-29-7 (5,6-diphenyl-1,2,4-triazin-3-yl)oxyacetyl hydrazide 
• 87121-41-3 (5,6-Diphenyl-[1,2,4]triazin-3-yloxy)-acetic acid [1-furan-2-yl-meth-(E)-ylidene]-hydrazide 
• 87121-37-7 (5,6-diphenyl-1,2,4-triazin-3-yl)oxyacetyl-N-(4-chlorobenzylidene) hydrazine 
• 87121-36-6 (5,6-Diphenyl-[1,2,4]triazin-3-yloxy)-acetic acid [1-(4-hydroxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 87121-30-0 5-(5,6-Diphenyl-[1,2,4]triazin-3-yloxymethyl)-4-phenyl-4H-[1,2,4]triazole-3-thiol 
• 87121-38-8 (5,6-Diphenyl-[1,2,4]triazin-3-yloxy)-acetic acid [1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-hydrazide 
• 87121-35-5 5-(5,6-Diphenyl-[1,2,4]triazin-3-yloxymethyl)-4-p-tolyl-4H-[1,2,4]triazole-3-thiol 
• 87121-39-9 (5,6-Diphenyl-[1,2,4]triazin-3-yloxy)-acetic acid [1-naphthalen-2-yl-meth-(E)-ylidene]-hydrazide 

Relevant articles and documents

Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory

A series of novel piperazine tethered biphenyl-3-oxo-1,2,4-triazine derivatives were designed, and synthesized. Amongst the synthesized analogs, compound 6g showed significant non-competitive inhibitory potential against acetylcholinesterase (AChE, IC50; 0.2 ± 0.01 μM) compared to standard donepezil (AChE, IC50: 0.1 ± 0.002 μM). Compound 6g also exhibited significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE (22.22 ± 1.11%) and showed good CNS permeability in PAMPA-BBB assay (Pe (exp), 6.93 ± 0.46). The in vivo behavioral studies of compound 6g indicated significant improvement in cognitive dysfunctions against scopolamine-induced amnesia mouse models. Further, ex vivo studies showed a significant AChE inhibition and reversal of the scopolamine-induced oxidative stress by compound 6g. Moreover, molecular docking and dynamics simulations of compound 6g showed a consensual binding affinity and active site interactions with the PAS and active catalytic site (CAS) residues of AChE.

Nano-sized silica supported FeCl3 as an efficient heterogeneous catalyst for the synthesis of 1,2,4-triazine derivatives

The one-pot synthesis of a series of 1,2,4-triazines from the reactions of semicarbazide or thiosemicarbazide with various α,β-dicarbonyl compounds under reflux conditions in a EtOH-H2O (9:1) mixture as solvent and catalyzed by nano-sized silica supported FeCl3 (FeCl3@SiO2) was investigated. The FeCl3 content of the catalyst was measured by atomic absorption to get the adsorption capacity. The reactions gave high yields of the product and the catalyst was easily separated and reused for successive reaction runs without significant loss of activity.

Structures and chemical equilibria of some N-heterocycles containing amide linkages

Structures and chemical equilibria of 5-carboxy-2-thiouracil (1), 5,6-diphenyl-3-hydroxy-1,2,4-triazine (2), 1-phenyl-3-methyl-5-pyrazolone (3) and 2-mercapto-4,6-dimethylpyrimidine hydrochloride (4) are reported. Their electronic transitions are assigned and pK values are evaluated and discussed.