160866-18-2Relevant academic research and scientific papers
Stereoselective synthesis of myo-inositol-1,3,4,5-tetrakisphosphate analoques from 6-deoxy D-inositol precursors
Dubreuil, Didier,Cleophax, Jeannine,De Almeida, Mauro Vieira,Verre-Sebrie,Pipelier, Muriel,Vass, Georges,Gero, Stephane D.
, p. 7573 - 7582 (1999)
The synthesis of 6-deoxy-D-myo-inositol-1,3,4,5-tetrakisphosphates is described. The access to opticaly pure Ins(1.3.4.5)P4 analogues was carried out from deoxy myo inositol precursors derived from D-galactose. Modification of Ins(1,3,4,5)P4 analogues by lipophilic substituents has been investigated in order to produce neutral phosphate derivatives aimed to be incorporated in cell membrane for in vivo evaluation.
