Stereoselective synthesis of myo-inositol-1,3,4,5-tetrakisphosphate analoques from 6-deoxy D-inositol precursors

Article abstract of DOI:10.1016/S0040-4020(99)00366-X

The synthesis of 6-deoxy-D-myo-inositol-1,3,4,5-tetrakisphosphates is described. The access to opticaly pure Ins(1.3.4.5)P₄ analogues was carried out from deoxy myo inositol precursors derived from D-galactose. Modification of Ins(1,3,4,5)P₄ analogues by lipophilic substituents has been investigated in order to produce neutral phosphate derivatives aimed to be incorporated in cell membrane for in vivo evaluation.