Stereoselective synthesis of myo-inositol-1,3,4,5-tetrakisphosphate analoques from 6-deoxy D-inositol precursors

DOI: 10.1016/S0040-4020(99)00366-X

Source and publish data:

Tetrahedron p. 7573 - 7582 (1999)

Update date:2022-08-03

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Authors:

Dubreuil, Didier

Cleophax, Jeannine

De Almeida, Mauro Vieira

Verre-Sebrie

Pipelier, Muriel

Vass, Georges

Gero, Stephane D.

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Article abstract of DOI:10.1016/S0040-4020(99)00366-X

The synthesis of 6-deoxy-D-myo-inositol-1,3,4,5-tetrakisphosphates is described. The access to opticaly pure Ins(1.3.4.5)P₄ analogues was carried out from deoxy myo inositol precursors derived from D-galactose. Modification of Ins(1,3,4,5)P₄ analogues by lipophilic substituents has been investigated in order to produce neutral phosphate derivatives aimed to be incorporated in cell membrane for in vivo evaluation.

Full text of DOI:10.1016/S0040-4020(99)00366-X

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