Tetrahedron p. 7573 - 7582 (1999)
Update date:2022-08-03
Topics:
Dubreuil, Didier
Cleophax, Jeannine
De Almeida, Mauro Vieira
Verre-Sebrie
Pipelier, Muriel
Vass, Georges
Gero, Stephane D.
The synthesis of 6-deoxy-D-myo-inositol-1,3,4,5-tetrakisphosphates is described. The access to opticaly pure Ins(1.3.4.5)P4 analogues was carried out from deoxy myo inositol precursors derived from D-galactose. Modification of Ins(1,3,4,5)P4 analogues by lipophilic substituents has been investigated in order to produce neutral phosphate derivatives aimed to be incorporated in cell membrane for in vivo evaluation.
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