1609013-05-9Relevant academic research and scientific papers
Discovery of 3-phenylquinolinylchalcone derivatives as potent and selective anticancer agents against breast cancers
Tseng, Chih-Hua,Tzeng, Cherng-Chyi,Hsu, Chih-Yao,Cheng, Chih-Mei,Yang, Chia-Ning,Chen, Yeh-Long
, p. 306 - 319 (2015)
A number of 3-phenylquinolinylchalcone derivatives were synthesized and evaluated in vitro for their antiproliferative activities against three breast cancer cell lines (MCF-7, MDA-MB-231, and SKBR-3), and a non-cancer normal epithelial cell line (H184B5F
Synthesis, antiproliferative and anti-dengue virus evaluations of 2-aroyl-3-arylquinoline derivatives
Tseng, Chih-Hua,Lin, Chun-Kuang,Chen, Yeh-Long,Hsu, Chih-Yao,Wu, Huey-Nan,Tseng, Chin-Kai,Lee, Jin-Ching
, p. 66 - 76 (2014/05/06)
A number of 2-aroyl-3-arylquinoline derivatives was synthesized and evaluated for their anti-Dengue virus activity. Both 2-(hydroxyphenylmethyl)-3- (4-methoxyphenyl)quinoline (13a) and 2-(4-hydroxybenzoyl)-3-(4-hydroxyphenyl) quinoline (17) were found to significantly inhibit the DENV2 RNA expression in Huh-7-DV-Fluc cells with a potency approximately equal to that of ribavirin and the inhibition is in a dose-dependent manner. Compounds 13a and 17 reduced DENV replication in both viral protein and mRNA levels, and no significant cell cytotoxicity was detected, with greater than 50% viability of Huh-7-DV-Fluc cells at a concentration of 100 μM. However, significant cytotoxicity was detected for the positive ribavirin. In addition, we performed infectious assay to further verify the inhibitory activity of 13a and 17 on DENV replication in protein and RNA levels. On the other hand, compounds 19a-19c exhibited IC 50 values ranged from 4.47 to 8.68 μM against A549, H1299, MCF-7, and Huh-7 which were approximately equal potent to the positive topotecan. Structural optimization of lead compounds, 13a and 17, and their detailed molecular mechanism of action are ongoing.
