160906-98-9Relevant articles and documents
New tetracyclic 1,4-oxazepines constructed via practically simple tandem condensation strategy from readily available synthons
Sapegin, Alexander V.,Kalinin, Stanislav A.,Smirnov, Alexey V.,Dorogov, Mikhail V.,Krasavin, Mikhail
, p. 1077 - 1083 (2014/01/23)
A streamlined synthetic methodology towards novel tetracyclic 1,4-oxazepines from readily available precursors is described. The compounds, designed as more soluble version of the earlier described, poorly soluble dibenzo[b,f][1,4]oxazepines, were obtained in high yields and as a single regioisomer as a result of three tandem chemical events - nucleophilic aromatic substitution, Smiles rearrangement and denitrocyclization.
Identification of a sulfonamide series of CCR2 antagonists
Peace, Simon,Philp, Joanne,Brooks, Carl,Piercy, Val,Moores, Kitty,Smethurst, Chris,Watson, Steve,Gaines, Simon,Zippoli, Mara,Mookherjee, Claudette,Ife, Robert
supporting information; experimental part, p. 3961 - 3964 (2010/09/03)
A series of sulfonamide CCR2 antagonists was identified by high-throughput screening. Management of molecular weight and physical properties, in particular moderation of lipophilicity and study of pKa, yielded highly potent CCR2 antagonists exh
PYRIDINYL SULFONAMIDE MODULATORS OF CHEMOKINE RECEPTORS
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Page/Page column 15, (2010/11/27)
The present invention relates to compounds of following formula (I) or pharmaceutically acceptable salts thereof; pharmaceutical compositions containing them, and their use in the treatment of disorders mediated by the CCR-2 receptor.
Imidazopyridinone derivatives and their use as phosphodiesterase inhibitors
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, (2008/06/13)
A compound (Ia): wherein the variables are defined in the specification, its prodrug or a pharmaceutically acceptable salt thereof useful in the treatment of angina, hypertension etc.