160907-95-9

Upstream product

• 67226-77-1 tert-butyldimethylsilyl 3-[(tertbutyldimethylsilyl)oxy]benzoate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99-06-9 3-Carboxyphenol 

Downstream Products

• 342803-45-6 3-tert-butyldimethylsilyloxybenzoyl chloride 
• 1098620-08-6 3-(t-butyldimethylsilyloxy)-N-methoxy-N-methylbenzamide 
• 389104-64-7 4-hydroxybutyl 3-[(tert-butyldimethylsilyl)oxy]benzoate 
• 1346005-62-6 4-[(4-methoxybenzyl)oxy]butyl 3-[(tert-butyldimethylsilyl)oxy]benzoate 
• 1351066-94-8 5-(tert-butyldimethylsilyloxy)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide 
• 1428858-79-0 2-butyl-5-((tert-butyldimethylsilyl)oxy)-N-(quinolin-8-yl)benzamide 
• 1377585-42-6 N-[3-(tert-butyldimethylsilyloxy)benzoyl]-S-methyl-S-phenylsulfoximine 

Relevant academic research and scientific papers

The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl- d -Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl- d -Aspartate Receptors

We have identified a series of positive allosteric NMDA receptor (NMDAR) modulators derived from a known class of GluN2C/D-selective tetrahydroisoquinoline analogues that includes CIQ. The prototypical compound of this series contains a single isopropoxy moiety in place of the two methoxy substituents present in CIQ. Modifications of this isopropoxy-containing scaffold led to the identification of analogues with enhanced activity at the GluN2B subunit. We identified molecules that potentiate the response of GluN2B/GluN2C/GluN2D, GluN2B/GluN2C, and GluN2C/GluN2D-containing NMDARs to maximally effective concentrations of agonist. Multiple compounds potentiate the response of NMDARs with submicromolar EC50 values. Analysis of enantiomeric pairs revealed that the S-(-) enantiomer is active at the GluN2B, GluN2C, and/or GluN2D subunits, whereas the R-(+) enantiomer is only active at GluN2C/D subunits. These results provide a starting point for the development of selective positive allosteric modulators for GluN2B-containing receptors.

Cell sugar transport channel inhibitor

The invention discloses a cell sugar transport channel inhibitor of which the structure is shown as a formula (I). The cell sugar transport channel inhibitor disclosed by the invention can target a cell sugar transport channel, and inhibit tumor cell prol

One-step modification to identify dual-inhibitors targeting both pancreatic triglyceride lipase and Niemann-Pick C1-like 1

Pancreatic triglyceride lipase (PTL) and Niemann-Pick C1-like 1 (NPC1L1) have been identified as attractive therapeutic targets for obesity and hypercholesteremia, respectively. Obesity and hypercholesteremia usually co-exist, however no dual-inhibitors against PTL and NPC1L1 were reported for the treatment of obesity patients with hypercholesteremia so far. In this work, molecular hybridization-based one-step modification screening identified a potent dual-inhibitor against PTL and NPC1L1. Compound P1-11 has IC50 values of 2.1 μM against PTL through covalent binding, as well as significantly reduces cholesterol absorption in a non-competitive inhibitory manner. Molecule docking and molecular dynamics studies revealed the reason of its activity to both PTL and NPC1L1. Moreover, the gene and protein expression levels of PTL and NPC1L1 were also determined respectively after the treatment of P1-11. Development of dual-inhibitors against PTL and NPC1L1 could provide novel treatment options for obesity patients with hypercholesteremia. The results of current research would great support the development of dual-inhibitors against PTL and NPC1L1.

C?O Activation by a Rhodium Bis(N-Heterocyclic Carbene) Catalyst: Aryl Carbamates as Arylating Reagents in Directed C?H Arylation

Despite recent progress in the catalytic transformation of inert phenol derivatives as alternatives to aryl halides and triflates, attempts at the cross-coupling of inert phenol derivatives with the C?H bonds of arenes have met with limited success. Herein, we report the rhodium-catalyzed cross-coupling of aryl carbamates with arenes bearing a convertible directing group. The key to success is the use of an in situ generated rhodium bis(N-heterocyclic carbene) species as the catalyst, which can promote activation of the inert C(sp2)?O bond in aryl carbamates.

Directing the crystallization of dehydro[24]annulenes into supramolecular nanotubular scaffolds

The self-assembly of a series of dehydro[24]annulene derivatives into columnar stacks has been examined for its latent ability to form -conjugated carbon-rich nanotubular structures through topochemical polymerizations. We have studied the parameters affe

Mild, selective deprotection of PMB ethers with triflic acid/1,3-dimethoxybenzene

An efficient method for the cleavage of the p-methoxybenzyl protecting group of several alcohols in the presence of 0.5 equiv of trifluoromethanesulfonic acid and 1,3-dimethoxybenzene in dichloromethane at room temperature is described.

Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L

A series of thiosemicarbazone analogs based on the benzophenone, thiophene, pyridine, and fluorene molecular frameworks has been prepared by chemical synthesis and evaluated as small-molecule inhibitors of the cysteine proteases cathepsin L and cathepsin B. The two most potent inhibitors of cathepsin L in this series (IC50 50 = 150.8 nM). Bromine substitution in the thiophene series results in compounds that demonstrate only moderate inhibition of cathepsin L. The two most active analogs in the benzophenone thiosemicarbazone series are highly selective for their inhibition of cathepsin L versus cathepsin B.

Ultra-Sensitive Chemiluminescent Substrates for Enzymes and Their Conjugates

New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridanebased compounds and (1,2)-dioxetanes. Among the new acridanebased compounds are water-soluble acridanes, enhancer coupled acridanes, bis and trisacri