3-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid

Base Information

Chemical Name:3-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid
CAS No.:160907-95-9
Molecular Formula:C13H20O3Si
Molecular Weight:252.386
Hs Code.:
DSSTox Substance ID:DTXSID10593190
Nikkaji Number:J3.485.600A
Wikidata:Q82487627
Mol file:160907-95-9.mol

Synonyms:160907-95-9;3-((tert-Butyldimethylsilyl)oxy)benzoic acid;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]BENZOIC ACID;3-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid;SCHEMBL2989104;DTXSID10593190;HBTRYLXBYNEGGD-UHFFFAOYSA-N;3-tert-Butyldimethylsilyloxybenzoic Acid;DB-378434;3-(tert-butyl-dimethyl-silanyloxy)-benzoic acid;EN300-6489651;3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]benzoic acid

Suppliers and Price of 3-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 3-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:252.11817103
Heavy Atom Count:17
Complexity:281

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1=CC=CC(=C1)C(=O)O

Technology Process of 3-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid

There total 3 articles about 3-{[tert-Butyl(dimethyl)silyl]oxy}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 99-06-9
3-Carboxyphenol

: 160907-95-9
3-((tert-butyldimethylsilyl)oxy)benzoic acid

Guidance literature:: tert-butyldimethylsilyl chloride; 3-Carboxyphenol; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃;

With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.7b00239

Reference yield: 76.0%

: 67226-77-1
tert-butyldimethylsilyl 3-[(tertbutyldimethylsilyl)oxy]benzoate

: 160907-95-9
3-((tert-butyldimethylsilyl)oxy)benzoic acid

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 2h;
DOI:10.1002/anie.201610409

Reference yield:

: 99-06-9
3-Carboxyphenol

: 160907-95-9
3-((tert-butyldimethylsilyl)oxy)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 21 °C

2: acetic acid / tetrahydrofuran; water / 2 h / 21 °C

With 1H-imidazole; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2011.08.102