160912-89-0

Upstream product

• 1466-88-2 2-nitrocinnamic aldehyde 
• 2181-42-2 trimethylsulphonium iodide 
• 399513-51-0 (+/-)-(3E)-1-chloro-4-(2-nitro-phenyl)-but-3-en-2-ol 

Downstream Products

• 1357163-02-0 (1E,4R,5S)-5-methyl-1-(2-nitrophenyl)hepta-1,6-dien-4-ol 
• 1357163-03-1 (1E,4R,5R)-5-methyl-1-(2-nitrophenyl)hepta-1,6-dien-4-ol 
• 399513-53-2 (1E,4R)-1-(2-nitro-phenyl)-hepta-1,6-dien-4-ol 

Relevant academic research and scientific papers

Chemoselective cross metathesis of bishomoallylic alcohols: Rapid access to fragment A of the cryptophycins

Equation presented. The racemic or enantioselective allylation of in situ formed β,γ-unsaturated aldehydes provides efficient access to bishomoallylic alcohols from readily available 2-vinyloxiranes. These products, when subjected to modified Grubbs cross

Enantioselective allylation of β,γ-unsaturated aldehydes generated via Lewis acid induced rearrangement of 2-vinyloxiranes

(matrix presented) 2-Vinyloxiranes have been found to be excellent surrogates to β,γ-unsaturated aldehydes. These valuable electrophiles, generated in situ by treatment of a 2-vinyloxirane with a catalytic amount of Sc(OTf)3, are effectively tr

"Vinylogs" and "acetylenylogs" of β-adrenergic agents

Vinylogous (Groups III and V) and acetylenologous (Group IV) analogs of the classical β-adrenergic agents - stimulants and blockers - were prepared in order to evaluate the effect of degree of saturation, position of unsaturation and rigidity of the chain

Hypoxic radiosensitizers: Substituted styryl derivatives

A number of novel styryl epoxides, N-substituted-styryl-ethanolamines, N-mono and N,N'-bis-(2-hydroxyethyl)-cinnamamides - analogues to the known radiosensitizers RSU- 1069, pimonidazole and etanidazole - display selective hypoxic radiosensitizing activity. The styryl group, especially when substituted by electron withdrawing groups, was found to be bioisosteric to the nitroimidazolyl functionality. The most active derivative 2-(2'-nitrophenyl)ethen-1-yl-oxirane 8a displayed a sensitizer enhancement ratio (SER) of 5 relative to misonidazole.