1609178-46-2

Upstream product

• 1609178-42-8 (S)-2-((S)-5,5-dimethyl-4,6-dioxaspiro[2.5]octan-7-yl)propanal 
• 1609178-43-9 (S)-5,5-dimethyl-7-((R,E)-4-phenylbut-3-en-2-yl)-4,6-dioxaspiro[2.5]octane 
• 1609178-44-0 (3S,4R,E)-methyl 3-hydroxy-4-methyl-6-phenylhex-5-enoate 
• 1609178-45-1 (3S,4R,E)-methyl 3-(tert-butyldimethylsilyloxy)-4-methyl-6-phenylhex-5-enoate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 642087-12-5 (E)-(3S,4R)-3-Hydroxy-4-methyl-6-phenyl-hex-5-enal 
• 208581-49-1 (3S,4R)-4-methyl-6-phenylhex-5-ene-1,3-diol 

Relevant academic research and scientific papers

Syn -Selective crotylation of aldehydes using bismuth-crotyl bromide-(1-butyl-3-methylimidazolium bromide) combination: Some synthetic applications

The Bi-[bmim][Br] combination has been found to offer high syn-selectivity in the crotylation of aldehydes with crotyl bromide using practically stoichiometric amounts of the reagents. The room temperature ionic liquid (RTIL), [bmim][Br], activated Bi metal in the presence of oxygen to produce crotylbismuthdibromide, which reacted with the aldehydes at room temperature. The major anti-syn diastereomeric product obtained from the crotylation of (R)-cyclohexylideneglyceraldehyde was utilized for the synthesis of dictyostatin and cryptophycin segments, and (+)-cis-aerangis lactone, using standard synthetic protocols.

A cyclopropanol-based approach to synthesis of Unit A of the cryptophycins

A new asymmetric synthesis of Unit A of the cryptophycins has been carried out yielding 13% of the target product over 14 steps. The key steps of the synthesis were diastereoselective hydroboration-oxidation reactions performed on the alkenyl moiety of a