1609183-47-2Relevant academic research and scientific papers
Nickel-catalyzed C-H alkylations: Direct secondary alkylations and trifluoroethylations of arenes
Song, Weifeng,Lackner, Sebastian,Ackermann, Lutz
supporting information, p. 2477 - 2480 (2014/03/21)
A versatile nickel catalyst allowed for C-H alkylations of unactivated arenes with challenging secondary alkyl bromides and chlorides. The high catalytic efficacy also set the stage for direct secondary alkylations of indoles as well as C-H trifluoroethylations with ample substrate scope. In an absence of activation: A robust nickel(II) catalyst enabled secondary alkylations of unactivated aryl C-H bonds with secondary alkyl bromides and chlorides with ample substrate scope. Based on this system the first C-H trifluoroethylations of arenes with unactivated C-H bonds could be carried out (see scheme; Q=8-quinolinyl). Copyright
